Effect of the LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF on pregnancy in the rat

  • Contraception. 1979 Feb;19(2):185-90. doi: 10.1016/s0010-7824(79)80030-x.
C Rivier ,  J Rivier ,  W Vale
PMID: 371912 DOI: 10.1016/s0010-7824(79)80030-x
Abstract

The potent LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF (Antag.) has been examined for its effect in mated female rats. While 1.25 mg Antag. given b.i.d. for 7 days after mating prolongs pregnancy, the administration of 2.5 mg Antag. b.i.d. for the same period results in the complete absence of developing fetuses.

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