PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity

  • J Antibiot (Tokyo). 1986 Jun;39(6):800-3. doi: 10.7164/antibiotics.39.800.
T A Smitka ,  R H Bunge ,  J H Wilton ,  G C Hokanson ,  J C French ,  C H He ,  J Clardy
PMID: 3755428 DOI: 10.7164/antibiotics.39.800
Abstract

A new, highly substituted phenazine with antitumor activity was isolated from the culture broth of a Streptomyces sp. This compound, whose structure was determined by spectroscopic methods and verified by X-ray diffraction analysis, was found to be methyl 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylate.

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