Effects of pyrrolopyrimidine derivatives on cancer cells cultured in vitro and potential mechanism

  • Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct 28. doi: 10.1007/s00210-023-02799-6.
Zuhal Kilic-Kurt  1 ,  Aybuke Celik  2 ,  Filiz Bakar-Ates  2
Affiliations
  • 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Yenimahalle, 06560, Ankara, Turkey. [email protected].
  • 2. Department of Biochemistry, Faculty of Pharmacy, Ankara University, Yenimahalle, 06560, Ankara, Turkey.
PMID: 37891256 DOI: 10.1007/s00210-023-02799-6
Abstract

In this study, the Anticancer activities of some pyrrolopyrimidine derivatives were evaluated. Compound 3 is the most cytotoxic compound on MCF-7 Cancer cells with an IC50 value of 23.42 µM. Also, compound 3 induced Apoptosis and the ROS(+) cell population in MCF-7 cells. Moreover, it significantly reduced MMP-9 activity, having 42.16 ± 5.10% and 58.28 ± 1.96% inhibitory activities at 10 µM and 50 µM concentrations, respectively. Molecular docking results supported the activity, showing key hydrogen bonds with the binding site of MMP-9. Therefore, compound 3 might be a lead compound for the development of potent MMP-9 inhibitors.

Keywords
Anticancer; MMP-9 inhibitor activity; Oxidative stress; Pyrrolopyrimidine derivatives.
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