Two New Prostaglandin-Like Compounds from Callicarpa arborea Roxb and Their NLRP3 Inflammasome Activation Inhibitory Activity

  • Chem Biodivers. 2023 Dec;20(12):e202301628. doi: 10.1002/cbdv.202301628.
Muhammad Aurang Zeb  1 ,  Ling Ding  1 ,  Meng-Ru Wang  1 ,  Wen-Chao Tu  1 ,  Xiao-Li Li  1 ,  Xing-Jie Zhang  1 ,  Wei-Lie Xiao  1
Affiliations
  • 1. Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Centre for Natural Products, School of Chemical Science and Technology and School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650500, People's Republic of China.
PMID: 37964626 DOI: 10.1002/cbdv.202301628
Abstract

Two new prostaglandin-like compounds callicarboric acids A-B (1-2), along with six known compounds (3-8) were isolated from the stems of Callicarpa arborea Roxb. Their structures were determined with the help of modern spectroscopic techniques such as NMR, UV, IR, HR-ESI-MS, ECD, and ORD with the assistance of quantum chemical calculations. Compound 1 exhibited remarkable anti-NLRP3 inflammasome activation potential, demonstrating an IC50 value of 0.74 μM. Additionally, by reducing GSDMD-NT production, inhibiting Caspase-1 activation, and suppressing IL-1β secretion, it effectively mitigated NLRP3 inflammasome-induced Pyroptosis in J774A.1 cells. These findings indicate that compound 1 possesses the capability to be a valuable candidate for further research and development as an NLRP3 inflammasome inhibitor.

Keywords
Callicarpa; DP4+; NLRP3 inflammasome; prostaglandin; spectroscopy.
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