Discovery of a New Compound, Erinacerin W, from the Mycelia of Hericium erinaceus, with Immunomodulatory and Neuroprotective Effects

  • Molecules. 2024 Feb 9;29(4):812. doi: 10.3390/molecules29040812.
Jing-Yi Lin  1 ,  Yen-Po Chen  1 ,  Ting-Wei Lin  1 ,  Tsung-Ju Li  1 ,  Yu-Wen Chen  1 ,  I-Chen Li  1 ,  Chin-Chu Chen  1  2  3  4
Affiliations
  • 1. Biotech Research Institute, Grape King Bio Ltd., Long Tan Dist., Taoyuan City 325, Taiwan.
  • 2. Institute of Food Science and Technology, National Taiwan University, Taipei City 106, Taiwan.
  • 3. Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei City 104, Taiwan.
  • 4. Department of Bioscience Technology, Chung Yuan Christian University, Zhong-Li Dist., Taoyuan City 320, Taiwan.
PMID: 38398564 DOI: 10.3390/molecules29040812
Abstract

One new compound with an isoindolinone skeleton, along with erinacines A, C, and S, was isolated from the mycelia of Hericium erinaceus, an edible fungus with a long history of use in traditional Chinese medicine. Based on analysis of MS and NMR spectral data, the structure of the compound was identified as (2E,6E)-8-(2-(1-carboxy-3-methylbutyl)-4,6-dihydroxy-1-oxoisoindolin-5-yl)-2,6-dimethylocta-2,6-dienoic acid. In light of this discovery, we have given this compound the name erinacerin W. Using a co-culture in vitro LPS-activated BV2 microglia-induced SH-SY5Y neuroinflammation model, the results showed that erinacerin W demonstrated protection against the LPS-activated BV-2 cell-induced overexpression of IL-6, IL-1β, and TNF-α on SH-SY5Y cells. This finding may provide potential therapeutic approaches for central nervous disorders.

Keywords
Hericium erinaceus mycelia; NMR; erinacerin W; immunomodulatory; neuroprotection; novel compound.
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