Carbazole and Quinazolinone Derivatives from a Fluoride-Tolerant Streptomyces Strain OUCMDZ-5511

  • J Agric Food Chem. 2024 Mar 27;72(12):6424-6431. doi: 10.1021/acs.jafc.4c00780.
Yue Liu  1 ,  Junsheng Liu  2 ,  Pengcheng Yan  1 ,  Konthorn Kachanuban  1  3 ,  Peipei Liu  1 ,  Aiqun Jia  2 ,  Weiming Zhu  1  4
Affiliations
  • 1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
  • 2. Key Laboratory of Tropical Biological Resources of Ministry Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
  • 3. Department of Fishery Product, Faculty of Fisheries of Kasetsart University, Bangkok 10900, Thailand.
  • 4. Key Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao 266237, China.
PMID: 38470989 DOI: 10.1021/acs.jafc.4c00780
Abstract

Six new 9H-carbazole derivatives (1-6) and nine previously reported compounds (7-15) were isolated from a fermented solid medium of the Thailand mangrove-derived Streptomyces strain, OUCMDZ-5511, under fluoride stress. Compounds 2-5, 12, and 15 were exclusively present in the fluoride-supplemented fermentation medium, while compounds 7-9, 13, and 14 were newly discovered natural products. The molecular structures of the compounds were identified by a spectroscopic analysis. The new compound 2 displayed antiquorum sensing activity against Chromobacterium violaceum ATCC 12472 by reducing the violacein production and inhibiting the biofilm formation in a concentration-dependent manner. The study revealed that compound 2 could be a novel potential inhibitor of quorum sensing.

Keywords
9H-carbazole; Streptomyces; antiquorum sensing; fluoride tolerance.
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