Discovery of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors

  • Eur J Med Chem. 2025 Dec 15:300:118145. doi: 10.1016/j.ejmech.2025.118145.
Baku Acharya  1 ,  Maha Hanafi  2 ,  Luke Enemark  1 ,  Daniel Armstrong  1 ,  Debasmita Saha  3 ,  Sayem Miah  4 ,  Brendan Frett  5
Affiliations
  • 1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States.
  • 2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11526, Egypt.
  • 3. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States; Conrad Prebys Centre for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, United States.
  • 4. Department of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States. Electronic address: [email protected].
  • 5. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, United States. Electronic address: [email protected].
PMID: 40967071 DOI: 10.1016/j.ejmech.2025.118145
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