Novel Pyridopyrazine Derivatives as Inverse Agonists of the G Protein-Coupled Receptor 6

  • ACS Med Chem Lett. 2026 Jan 13;17(2):280-281. doi: 10.1021/acsmedchemlett.5c00748.
Yinlong Li  1 ,  Steven H Liang  1  2
Affiliations
  • 1. Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
  • 2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States.
PMID: 41704355 DOI: 10.1021/acsmedchemlett.5c00748
Abstract

This patent highlight describes the development and evaluation of novel pyridopyrazine analogs as potent inverse agonists for G protein-coupled receptor 6 (GPR6). It discloses synthetic methods and pharmacological properties of these new GPR6 modulators.

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