Modification of seldomycin factor 5 at C-3'

  • J Antibiot (Tokyo). 1978 May;31(5):441-50. doi: 10.7164/antibiotics.31.441.
R E Carney ,  J B McAlpine ,  M Jackson ,  R S Stanaszek ,  W H Washburn ,  M Cirovic ,  S L Mueller
PMID: 670086 DOI: 10.7164/antibiotics.31.441
Abstract

Attempted removal of the 3'-hydroxyl group of seldomycin factor 5 via displacement of a sulfonate ester has led to 3'-epi-seldomycin factor 5. Removal of the hydroxyl group has been effected by the Barton procedure. The Antibacterial activity of 3'-epi- and 3'-deoxyseldomycin factor 5 against various aminoglycoside-resistant strains is discussed.

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