Gilvocarcins, new antitumor antibiotics. 4. Mode of action

  • J Antibiot (Tokyo). 1982 Aug;35(8):1038-41. doi: 10.7164/antibiotics.35.1038.
F Tomita ,  K Takahashi ,  T Tamaoki
PMID: 6815145 DOI: 10.7164/antibiotics.35.1038
Abstract

The mode of action of gilvocarcins was studied. Gilvocarcins V, M and A possessed Antibacterial activities decreasing in that order. Gilvocarcin V inhibited DNA synthesis in Bacillus subtilis through strong interaction with DNA and resulting cleavage. Gilvocarcin M showed interaction with DNA and a small change in DNA mobility upon electrophoresis in Agarose gel, while gilvocarcin A showed no interaction with DNA, thus reflecting their relative biological activities.

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