Malioxamycin, a new antibiotic with spheroplast-forming activity. II. Structural elucidation and total synthesis

  • J Antibiot (Tokyo). 1980 Nov;33(11):1220-3. doi: 10.7164/antibiotics.33.1220.
S Takahashi ,  M Takeuchi ,  M Inukai ,  M Arai
PMID: 7251467 DOI: 10.7164/antibiotics.33.1220
Abstract

Malioxamycin (1) is a new Antibiotic produced by Streptomyces lydicus No. 15748. The structure of malioxamycin has been determined by nmr and mass spectra to possess a hydroxamic acid bond between L-valine and D-malic acid. This structure was confirmed by total synthesis of the Antibiotic with (R)-aminooxysuccinic acid and the active ester of L-valine.

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