Taxol and its related taxoids from the needles of Taxus sumatrana

  • Chem Pharm Bull (Tokyo). 1995 Feb;43(2):365-7. doi: 10.1248/cpb.43.365.
I Kitagawa  1 ,  T Mahmud ,  M Kobayashi ,  Roemantyo ,  H Shibuya
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Osaka University, Japan.
PMID: 7728941 DOI: 10.1248/cpb.43.365
Abstract

Through bioassay-guided separation of the chemical constituents of the needles of Taxus sumatrana, taxol (1), cephalomannine (2), and a new taxoid 19-hydroxy-13-oxobaccatin III (8) have been isolated together with 7-epi-10-deacetyltaxol (3), 7-epi-10-deacetylcephalomannine (4), baccatin III (5), 19-hydroxybaccatin III (6), and 10-deacetyl-13-oxobaccatin III (7). The chemical structure of 8 has been elucidated on the Bases of its chemical and physicochemical properties.

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