Crocacin, a new electron transport inhibitor from Chondromyces crocatus (myxobacteria). Production, isolation, physico-chemical and biological properties

  • J Antibiot (Tokyo). 1994 Aug;47(8):881-6. doi: 10.7164/antibiotics.47.881.
B Kunze  1 ,  R Jansen ,  G Höfle ,  H Reichenbach
Affiliations
  • 1. GBF, Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.
PMID: 7928674 DOI: 10.7164/antibiotics.47.881
Abstract

Crocacin was isolated from the biomass of the myxobacterium Chondromyces crocatus, strain Cm c3. It inhibited the growth of a few Gram-positive bacteria and a wide spectrum of yeasts and molds. In beef heart submitochondrial particles, crocacin blocked the electron transport within the bc1-segment (complex III) and caused a red shift in the reduced spectrum of cytochrome b with a maximum at 569 nm.

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