Novel nematocidal agents from Curcuma comosa

  • J Nat Prod. 1994 Feb;57(2):230-5. doi: 10.1021/np50104a006.
T M Jurgens  1 ,  E G Frazier ,  J M Schaeffer ,  T E Jones ,  D L Zink ,  R P Borris ,  W Nanakorn ,  H T Beck ,  M J Balick
Affiliations
  • 1. Merck Research Laboratories, Rahway, New Jersey 07065.
PMID: 8176399 DOI: 10.1021/np50104a006
Abstract

Curcuma comosa is a member of the economically important plant family, Zingiberaceae. A methanolic Extract of C. comosa was shown to be nematocidal when tested against the free-living nematode Caenorhabditis elegans. Five diphenylheptanoids [1-5], one new and four known, have been isolated and shown to be responsible for the activity. This is the first report of three of these compounds [1, 2, 4] being isolated from a natural source.

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