Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2

  • J Virol. 1993 Nov;67(11):6847-52. doi: 10.1128/JVI.67.11.6847-6852.1993.
J M Bergelson  1 ,  N St John ,  S Kawaguchi ,  M Chan ,  H Stubdal ,  J Modlin ,  R W Finberg
Affiliations
  • 1. Laboratory of Infectious Disease, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
PMID: 8411387 DOI: 10.1128/JVI.67.11.6847-6852.1993
Abstract

Anti-VLA-2 antibodies protected HeLa cells from Infection by echoviruses 1 and 8 but not from Infection by Other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for Infection by echoviruses 1 and 8 but that Other echovirus serotypes must bind receptors Other than VLA-2.