Dactylfungins, novel antifungal antibiotics produced by Dactylaria parvispora

  • J Antibiot (Tokyo). 1993 Jan;46(1):48-55. doi: 10.7164/antibiotics.46.48.
J Xaio  1 ,  S Kumazawa ,  N Yoshikawa ,  T Mikawa ,  Y Sato
Affiliations
  • 1. Biosciences Laboratory, Mitsubishi Kasei Corporation, Yokohama, Japan.
PMID: 8436559 DOI: 10.7164/antibiotics.46.48
Abstract

Novel antifungal Antibiotics, designated as dactylfungins A (1) and B (3), were isolated from the culture broth of Dactylaria parvispora D500. Dactylfungins A and B were found to be new substances containing an alpha-pyrone and a gamma-pyrone ring, respectively, which conjoined with a polyalcohol moiety and a long side chain, based on NMR spectral analyses. The Antibiotics were active against Candida pseudotropicalis and Other fungi, with an MIC value at less than 10 micrograms/ml.

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