Identification of immunosuppressive components of a mushroom, Lactarius flavidulus

  • Chem Pharm Bull (Tokyo). 1993 Apr;41(4):654-8. doi: 10.1248/cpb.41.654.
H Fujimoto  1 ,  Y Nakayama ,  M Yamazaki
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Chiba University, Japan.
PMID: 8508468 DOI: 10.1248/cpb.41.654
Abstract

Three metabolites having a suppressive effect on proliferation of mouse lymphocytes stimulated with mitogens such as concanavalin A (Con A) and lipopolysaccharide (LPS) were isolated from a mushroom, Lactarius flavidulus, and identified as geranylphenols, flavidulols A, B and C, respectively, which had previously been isolated from the same mushroom. The IC50 values of flavidulols A, B and C were found to be 8.9, 4.9 and 36.3 micrograms/ml against Con A-induced proliferation of mouse lymphocytes, and 6.7, 3.9 and 28.3 micrograms/ml against LPS-induced proliferation, respectively.

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