Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures

  • J Antibiot (Tokyo). 1996 Feb;49(2):119-23. doi: 10.7164/antibiotics.49.119.
S Stevens-Miles  1 ,  M A Goetz ,  G F Bills ,  R A Giacobbe ,  J S Tkacz ,  R S Chang ,  M Mojena ,  I Martin ,  M T Diez ,  F Pelaez ,  O D Hensens ,  T Jones ,  R W Burg ,  Y L Kong ,  L Huang
Affiliations
  • 1. Merck Research Laboratories, Rahway, New Jersey 07065, USA.
PMID: 8621349 DOI: 10.7164/antibiotics.49.119
Abstract

Cytosporin A, B and C, three antagonists of [125I]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp. during routine screening using semi-automated procedures. The most potent of these displayed an IC50 of 1.5-3 microM and was specific for angiotensin II AT2.

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