Molecular cloning and characterization of a new receptor for galanin

  • FEBS Lett. 1997 Apr 1;405(3):285-90. doi: 10.1016/s0014-5793(97)00196-8.
A D Howard  1 ,  C Tan ,  L L Shiao ,  O C Palyha ,  K K McKee ,  D H Weinberg ,  S D Feighner ,  M A Cascieri ,  R G Smith ,  L H Van Der Ploeg ,  K A Sullivan
Affiliations
  • 1. Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, NJ 07065, USA. [email protected]
PMID: 9108306 DOI: 10.1016/s0014-5793(97)00196-8
Abstract

Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior. Its effects are mediated through G-protein-coupled receptors (GPCR) for which only a single type has been cloned, GAL receptor 1 (GALR1). We describe the cloning of a second Galanin receptor type, GALR2, from rat hypothalamus. The GALR2 amino acid sequence is 38% identical to GALR1 and is pharmacologically similar to GALR1 when expressed in COS-7 cells. GALR2 is encoded by a single gene containing at least one intron and expressed in a diverse range of tissues.

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