Hydroxyakalone, a novel xanthine oxidase inhibitor produced by a marine bacterium, Agrobacterium aurantiacum

  • J Antibiot (Tokyo). 1997 Nov;50(11):916-8. doi: 10.7164/antibiotics.50.916.
H Izumida  1 ,  K Adachi ,  A Mihara ,  T Yasuzawa ,  H Sano
Affiliations
  • 1. Marine Biotechnology Institute, Shimizu Laboratory, Shizuoka, Japan.
PMID: 9592563 DOI: 10.7164/antibiotics.50.916
Abstract

A new Xanthine Oxidase Inhibitor named hydroxyakalone was isolated from the culture broth of a marine bacterium Agrobacterium aurantiacum N-81106. Structure of hydroxyakalone was determined to be 4-amino-1H-pyrazolo[3,4-d]pyrimidine-3-one-6-ol by the spectral studies of hydroxyakalone and its permethyl derivative. The concentration to induce 50% inhibition (IC50) was 4.6 microM against Xanthine Oxidase.

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