9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246

  • J Antibiot (Tokyo). 1997 Jul;50(7):546-50. doi: 10.7164/antibiotics.50.546.
W H Yeo  1 ,  B S Yun ,  N I Back ,  Y H Kim ,  S S Kim ,  E K Park ,  K S Whang ,  S H Yu
Affiliations
  • 1. Korea Ginseng & Tobacco Research Institute, Taejon, Korea.
PMID: 9711245 DOI: 10.7164/antibiotics.50.546
Abstract

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone Antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria and strong cytotoxic activity against some human Cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (Melanoma), A549 (lung), XF498 (central nervous system) with ED50 of 0.47-0.65 microgram/ml.

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