QSAR study of the peptidic fibrinogen inhibitors FK633, FR158999 and related derivatives, using a novel and useful hydrophobic descriptor (logPmw)

  • Bioorg Med Chem Lett. 1998 Sep 22;8(18):2483-8. doi: 10.1016/s0960-894x(98)00405-3.
A Tanaka  1 ,  M Murata ,  H Fujiwara
Affiliations
  • 1. Basic Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan.
PMID: 9873566 DOI: 10.1016/s0960-894x(98)00405-3
Abstract

A QSAR study using the novel hydrophobic descriptor (logPmw), which is a descriptor for membrane affinity, of our fibrinogen inhibitors FK633 (1), FR158999 (21), and related derivatives was performed, and resulted in good correlation (n = 19, s = 0.268, F = 6.38**, r = 0.667). Based on these results, we constructed a hypothesis by which these potent inhibitors bind to the receptor via the biomembrane and the C-terminal moiety functions as an anchor moiety.

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