Pyridoxylamine dihydrochloride
Based on 6 publication(s) in Google Scholar
Pyridoxylamine dihydrochloride is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 524-36-7
- Formula: C8H14Cl2N2O2
- Molecular Weight:241.11
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Pyridoxylamine dihydrochloride
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Int J Biol Sci. 2022 Jan 1;18(2):809-825. [Abstract]
- Phytomedicine. 2026 Jan:150:157744. [Abstract]
- Dev Cell. 2025 Nov 27:S1534-5807(25)00691-4. [Abstract]
- Molecules. 2023 Apr 11;28(8):3375. [Abstract]
- Skin Pharmacol Physiol. 2026 Mar 12:1-25. [Abstract]
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 524-36-7
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Appearance Solid
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Molecular Weight 241.11
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Formula C8H14Cl2N2O2
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Color White to off-white
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SMILES
OCC1=C(CN)C(O)=C(C)N=C1.[H]Cl.[H]Cl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Int J Biol Sci
The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration. [Abstract]2022 Jan 1;18(2):809-825. PMID: 35002527 -
Phytomedicine
Jinlida ameliorates diabetic kidney disease via gut microbiota-dependent production of pyridoxamine targeting renal AGEs/RAGE and TGF-β pathways. [Abstract]2026 Jan:150:157744. PMID: 41485293 -
Dev Cell
2025 Nov 27:S1534-5807(25)00691-4. PMID: 41314217 -
Molecules
Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]2023 Apr 11;28(8):3375. PMID: 37110608 -
Skin Pharmacol Physiol
Cysteinamide Enhances Fibroblast Survival and Wound Healing by Preventing Serum Deterioration in High-Glucose Conditions. [Abstract]2026 Mar 12:1-25. PMID: 41818405
Solvent & Solubility
H2O : 100 mg/mL (414.75 mM; Need ultrasonic)
DMSO : 100 mg/mL (414.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3 mg/mL (12.44 mM); Clear solution
This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3 mg/mL (12.44 mM); Clear solution
This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (414.75 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.1475 mL | 20.7374 mL | 41.4748 mL | 103.6871 mL |
| 5 mM | 0.8295 mL | 4.1475 mL | 8.2950 mL | 20.7374 mL | |
| 10 mM | 0.4147 mL | 2.0737 mL | 4.1475 mL | 10.3687 mL | |
| 15 mM | 0.2765 mL | 1.3825 mL | 2.7650 mL | 6.9125 mL | |
| 20 mM | 0.2074 mL | 1.0369 mL | 2.0737 mL | 5.1844 mL | |
| 25 mM | 0.1659 mL | 0.8295 mL | 1.6590 mL | 4.1475 mL | |
| 30 mM | 0.1382 mL | 0.6912 mL | 1.3825 mL | 3.4562 mL | |
| 40 mM | 0.1037 mL | 0.5184 mL | 1.0369 mL | 2.5922 mL | |
| 50 mM | 0.0829 mL | 0.4147 mL | 0.8295 mL | 2.0737 mL | |
| 60 mM | 0.0691 mL | 0.3456 mL | 0.6912 mL | 1.7281 mL | |
| 80 mM | 0.0518 mL | 0.2592 mL | 0.5184 mL | 1.2961 mL | |
| 100 mM | 0.0415 mL | 0.2074 mL | 0.4147 mL | 1.0369 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Pyridoxylamine dihydrochloride Related Classifications
HY-B1745A Related Classifications
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