1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Pyridoxylamine

Pyridoxylamine 

Cat. No.: HY-B1745
Handling Instructions

Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

For research use only. We do not sell to patients.

Pyridoxylamine Chemical Structure

Pyridoxylamine Chemical Structure

CAS No. : 85-87-0

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Description

Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1].

In Vivo

Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo[1].

Molecular Weight

168.19

Formula

C₈H₁₂N₂O₂

CAS No.

85-87-0

SMILES

OCC1=C(CN)C(O)=C(C)N=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Pyridoxylamine
Cat. No.:
HY-B1745
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