1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

Pyridoxylamine 

Cat. No.: HY-B1745
Handling Instructions

Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

For research use only. We do not sell to patients.

Pyridoxylamine Chemical Structure

Pyridoxylamine Chemical Structure

CAS No. : 85-87-0

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1 mg   Get quote  
5 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1].

In Vivo

Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9457 mL 29.7283 mL 59.4566 mL
5 mM 1.1891 mL 5.9457 mL 11.8913 mL
10 mM 0.5946 mL 2.9728 mL 5.9457 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

168.19

Formula

C₈H₁₂N₂O₂

CAS No.

85-87-0

SMILES

OCC1=C(CN)C(O)=C(C)N=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Pyridoxylamine
Cat. No.:
HY-B1745
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Pyridoxylamine

Cat. No.: HY-B1745