(Rac)-SCH900776
(Rac)-SCH900776 ((Rac)-MK-8776) is the racemate of SCH900776 (HY-15532). SCH900776 (MK-8776) is a potent and selective Chk1 inhibitor with an IC50 value of 3 nM.
For research use only. We do not sell to patients.
- CAS No.: 891495-88-8
- Formula: C15H18BrN7
- Molecular Weight:376.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Chk1 3 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.16 μM
Compound: 9b
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Inhibition of recombinant CDK2/Cyclin A expressed in insect Sf9 cells assessed as inhibition of [33P]-ATP incorporation into biotinylated histone H1 after 1 hr by liquid scintillation counting
Inhibition of recombinant CDK2/Cyclin A expressed in insect Sf9 cells assessed as inhibition of [33P]-ATP incorporation into biotinylated histone H1 after 1 hr by liquid scintillation counting
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[PMID: 21094607] |
Chemical Information
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CAS No. 891495-88-8
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Molecular Weight 376.26
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Formula C15H18BrN7
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SMILES
BrC=1C(=NC2=C(C=NN2C1N)C=3C=NN(C3)C)C4CNCCC4
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Synonyms
(Rac)-MK-8776
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Montano R, et al. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther. 2012 Feb;11(2):427-38. [Content Brief]
[2]. Guzi TJ, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-SCH900776 Related Classifications
HY-15532A Related Classifications
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