CDCP1 Protein, Mouse (Biotinylated, HEK293, His-Avi)
Based on 1 Customer Validation
The CDCP1 protein has been implicated in cell adhesion and matrix association, suggesting a role in important cellular interactions. Its phosphorylation suggests a dynamic function in regulating anchorage, migration, proliferation, or differentiation. CDCP1 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived CDCP1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The CDCP1 protein has been implicated in cell adhesion and matrix association, suggesting a role in important cellular interactions. Its phosphorylation suggests a dynamic function in regulating anchorage, migration, proliferation, or differentiation. CDCP1 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived CDCP1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
CDCP1 Protein appears to be involved in cell adhesion and cell matrix association, suggesting a role in mediating interactions crucial for cellular processes. Its potential involvement in the regulation of anchorage versus migration or proliferation versus differentiation, as indicated by its phosphorylation, implies a dynamic role in modulating cell behavior. Additionally, CDCP1 may serve as a novel marker for leukemia diagnosis and immature hematopoietic stem cell subsets, providing potential diagnostic and therapeutic insights. As a member of the tetraspanin web implicated in tumor progression and metastasis, CDCP1 interacts with key molecules including CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4, the serine protease ST14/MT-SP1, SRC, and PRKCG/protein kinase C gamma. The diversity of its interactions underscores its potential impact on cellular processes and suggests a multifaceted role in both normal and pathological conditions. Further exploration of CDCP1's functions and regulatory mechanisms could provide deeper insights into its contributions to cellular dynamics and its potential as a therapeutic target.
Anti-CDCP1 Antibody captured on CM5 Chip via Protein A can bind Biotinylated Mouse CDCP-1, His Tag with an affinity constant of 0.45 μM as determined in SPR assay (Biacore T200).
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-Avi;C-8*His
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Accession
Q5U462 (R25-A667)
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Molecular Construction
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N-term
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CDCP1 (R25-A667)
Accession # Q5U462 -
8*His-Avi
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C-term
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Protein Length
Partial
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Conjugation
Biotin
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Synonyms
CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With Src Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
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AA Sequence
RGTEASEIALPQRSGVTVSIKLGNPALPVKICYIVMSRQHITELIIRPGERKSFTFSCSNPEKHFVLKIEKNIDCMSGPCPFGEVHLQPSTSELPILNRTFIWDVRAHKSIGLELQFATPRLRQIGPGESCADGVTHSISGHIDATEVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHRRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANYPGGFPEDELMTWQFVVPAHLRASVSFLNFNVSNCERKEERVEYYIPGSTTNPEVFRLEDKQPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQRPQDESNKTYMVDLSRERTMSLTIEPRPVKHGRRFVPGCFVCLESRTCSTNVTLTAGSIHKISFLCDDLTRLWVNVEKTLSCLDHRYCYRQSFKLQVPDYILQLPVQLHDFSWKLLVPKDKLSLMLVPGQKLQQHTQERPCNTSFGYHVTSTTPGQDLYFGSFCSGGSIEKIQVKQNSSVTLRAYAPSFQQEVSKQGLIVSYTPYFKEEGIFTVTPDTKNKVYLRSPNWDRGLPALSSVSWNISVPSNQVACLTVLKERSGLACQSGRAFMIIQEQQSRAEEIFSLEEEVLPKPSFHHHSFWVNISNCSPMNGKQLDLLFWVTLTPRTVDLA
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Predicted Molecular Mass
75.3 kDa
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Molecular Weight
Approximately 80-100 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 5% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (239 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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