LRIG1 Protein, Cynomolgus (HEK293, His)
The LRIG1 protein acts as a feedback negative regulator of receptor tyrosine kinase signaling, enhancing receptor ubiquitination and promoting intracellular degradation. It interacts with various receptors, including EGFR/ERBB1, ERBB2, ERBB3, and ERBB4, through its extracellular leucine-rich repeats (LRR) and immunoglobulin-like domains. LRIG1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LRIG1 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The LRIG1 protein acts as a feedback negative regulator of receptor tyrosine kinase signaling, enhancing receptor ubiquitination and promoting intracellular degradation. It interacts with various receptors, including EGFR/ERBB1, ERBB2, ERBB3, and ERBB4, through its extracellular leucine-rich repeats (LRR) and immunoglobulin-like domains. LRIG1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LRIG1 protein, expressed by HEK293 , with C-His labeled tag.
Background
LRIG1 protein functions as a feedback negative regulator in receptor tyrosine kinase signaling pathways, employing a mechanism that enhances receptor ubiquitination and expedites intracellular degradation. It interacts with various receptor tyrosine kinases, including EGFR/ERBB1, ERBB2, ERBB3, and ERBB4, through its extracellular leucine-rich repeat (LRR) and immunoglobulin-like domains. However, the physiological relevance of these interactions is subject to controversy, as LRIG1 may exhibit low affinity for EGFR, and the interaction may occur only under conditions of elevated levels of both LRIG1 and the respective receptor tyrosine kinase proteins.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-8*His
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Accession
A0A2K5V8J9 (A34-T792)
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Gene ID/
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Molecular Construction
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N-term
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LRIG1 (A34-T792)
Accession # A0A2K5V8J9 -
8*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
LRIG1; Leucine-Rich Repeat Protein LRIG1; Leucine Rich Repeats And Immunoglobulin Like Domains 1; Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 1; LIG-1; Ortholog Of Mouse Integral Membrane Glycoprotein LIG-1; LIG1; DKFZP586O1624
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AA Sequence
AAGPRAPCAAACTCAGDSVDCGGRGLAALPGDLPAWTQSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAIPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSSNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEIAGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLMGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLAVPLEDRVVSAGETVALQCKATGNPPPRITWFKGDSPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTT
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Predicted Molecular Mass
84.2 kDa
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Molecular Weight
Approximately 90-110 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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