TYR Protein, Human (HEK293, His)

TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (HEK293, His) is the recombinant human-derived TYR protein, expressed by HEK293 , with N-6*His labeled tag.

TYR protein is a copper-containing oxidase crucial for pigment formation, playing a pivotal role in the synthesis of melanins and various polyphenolic compounds. Acting as the initiator of the melanin production pathway from tyrosine, TYR catalyzes the initial and rate-limiting step, hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine). Furthermore, it facilitates the oxidation of DOPA to DOPA-quinone and potentially mediates the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone, contributing to the complex cascade of reactions involved in melanin biosynthesis.

Human

HEK293

N-6*His

P14679-1 (H19-V377)

7299  [NCBI]

Partial

HFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQV

Approximately 42 kDa, based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.