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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
237 Results for "
Low-affinity
" in MedChemExpress (MCE) Product Catalog:
Products (237)
237 Results for "Low-affinity" in MCE Product Catalog:
Cat. No.: HY-P78634
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3RA; IL-3R-Alpha; Interleukin 3 Receptor Subunit Alpha; IL3R; CD123; HIL-3Ra; Interleukin 3 Receptor, Alpha (Low affinity); IL3RAY; Interleukin-3 Receptor Subunit Alpha; IL-3RA; IL-3 Receptor Subunit Alpha; IL3RX; IL-3R Subunit Alpha; IL3RY; CD123 Antig
Species:
Canine
Source:
HEK293
Cat. No.: HY-P700747
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3RA; IL-3R-Alpha; Interleukin 3 Receptor Subunit Alpha; IL3R; CD123; HIL-3Ra; Interleukin 3 Receptor, Alpha (Low affinity); IL3RAY; Interleukin-3 Receptor Subunit Alpha; IL-3RA; IL-3 Receptor Subunit Alpha; IL3RX; IL-3R Subunit Alpha; IL3RY; CD123 Antig
Species:
Human
Source:
HEK293
Cat. No.: HY-P701285
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3RA; IL-3R-Alpha; Interleukin 3 Receptor Subunit Alpha; IL3R; CD123; HIL-3Ra; Interleukin 3 Receptor, Alpha (Low affinity); IL3RAY; Interleukin-3 Receptor Subunit Alpha; IL-3RA; IL-3 Receptor Subunit Alpha; IL3RX; IL-3R Subunit Alpha; IL3RY; CD123 Antig
Species:
Human
Source:
HEK293
Cat. No.: HY-P704299
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL3RA; IL-3R-Alpha; Interleukin 3 Receptor Subunit Alpha; IL3R; CD123; HIL-3Ra; Interleukin 3 Receptor, Alpha (Low affinity); IL3RAY; Interleukin-3 Receptor Subunit Alpha; IL-3RA; IL-3 Receptor Subunit Alpha; IL3RX; IL-3R Subunit Alpha; IL3RY; CD123 Antig
Species:
Human
Source:
HEK293
Cat. No.: HY-P704715
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL3RA; IL-3R-Alpha; Interleukin 3 Receptor Subunit Alpha; IL3R; CD123; HIL-3Ra; Interleukin 3 Receptor, Alpha (Low affinity); IL3RAY; Interleukin-3 Receptor Subunit Alpha; IL-3RA; IL-3 Receptor Subunit Alpha; IL3RX; IL-3R Subunit Alpha; IL3RY; CD123 Antig
Species:
Human
Source:
HEK293
Cat. No.: HY-P705046
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL3RA; IL-3R-Alpha; Interleukin 3 Receptor Subunit Alpha; IL3R; CD123; HIL-3Ra; Interleukin 3 Receptor, Alpha (Low affinity); IL3RAY; Interleukin-3 Receptor Subunit Alpha; IL-3RA; IL-3 Receptor Subunit Alpha; IL3RX; IL-3R Subunit Alpha; IL3RY; CD123 Antig
Species:
Human
Source:
HEK293
Cat. No.: HY-117747
CAS No.: 151867-81-1
Synonyms: JCR 424; XM 323
Target:
Research Areas:
DMP 323 is a potent, nonpeptide cyclic urea inhibitor of HIV protease, effective against both HIV type 1 and type 2. Designed using structural information and database searching, it competitively inhibits the cleavage of both peptide and HIV-1 gag polyprotein substrates. DMP 323 shows comparable potency to other highly effective HIV protease inhibitors like A-80987 and Ro-31-8959. Importantly, its efficacy against HIV protease remains unaffected by human plasma or serum, suggesting low affinity for plasma proteins. Furthermore, DMP 323 demonstrates minimal inhibition of various mammalian proteases at concentrations much higher than those needed for HIV protease inhibition, highlighting its specificity for viral targets .
Cat. No.: HY-P990291
Target:
Research Areas:
Cat. No.: HY-U00050S
Synonyms: E-10-OH-NT-d3
Research Areas:
(E)-10-Hydroxynortriptyline-d3 (E-10-OH-NT-d3) is the deuterated-labeled (E)-10-Hydroxynortriptyline (HY-U00050). (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable norepinephrine uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression .
Cat. No.: HY-100966S
Synonyms: PF-06372865; CVL-865
Target:
Research Areas:
Darigabat (PF-06372865) is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). Darigabat is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. Darigabat can across the blood-brain barrier (BBB). Darigabat has anxiolytic activity and has the potential for epilepsy .
Cat. No.: HY-16950AR
CAS No.: 68392-35-8
Synonyms: Afimoxifene (Standard); 4-OHT (Standard)
Cat. No.: HY-178945
Research Areas:
KOR agonist 7 (Compound 29) is a highly selective κ-opioid receptor (KOR) agonist with a Ki of 138 nM. KOR agonist 7 shows no activity at μ- and δ-opioid receptors or σ1 receptor, and exhibits extremely low affinity for σ2 receptor (Ki = 2.8 μM). KOR agonist 7 significantly reduces the secretion of pro-inflammatory cytokines such as IL-6, TNF-α, and IFN-γ, while increasing the production of the anti-inflammatory cytokine IL-10. KOR agonist 7 downregulates the expression of the pro-inflammatory M1 macrophage marker CD80 and upregulates the anti-inflammatory M2 macrophage marker CD163. KOR agonist 7 holds potential for applications in analgesia and immune modulation .
Target:
Research Areas:
D3/5-HT receptor modulator-1 (compound 5i) is a selective dopamine D3 receptor and 5-HT2A receptor antagonist and a partial 5-HT1A receptor agonist. D3/5-HT receptor modulator-1 shows Ki values of 4.5 nM, 11.9 nM, and 15.3 nM for dopamine D3, 5-HT2A, and 5-HT2A receptors. D3/5-HT receptor modulator-1 has a low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels. D3/5-HT receptor modulator-1 has an atypical antipsychotic profile .
Cat. No.: HY-156807
CAS No.: 210751-39-6
Target:
Research Areas:
LY 367265 is a 5-hydroxytryptamine transporter (SERT) inhibitor (IC₅₀ = 3.1 nM) and a 5-HT₂A receptor antagonist (Kᵢ = 0.81 nM). LY 367265 has the inhibitory activity on the norepinephrine transporter (NET) of extremely weak (IC₅₀ > 1000 nM); it has low affinity for subtypes such as 5-HT₁B (Kᵢ = 490 nM) and 5-HT₁D (Kᵢ = 81 nM), showing high selectivity. LY 367265 concentration-dependently enhances of [³H]5-HT efflux (EC₅₀ = 250 nM). LY 367265 antagonizes the contraction response of Sumatriptan (HY-B0121B), indicating its functional antagonistic activity on 5-HT₁D-like receptors. LY 367265 can be used for the study of diseases such as anxiety disorders and post-traumatic stress disorder .
Cat. No.: HY-180503
CAS No.: 284041-36-7
Target:
Research Areas:
19-Nor-22-oxa-1a,25(OH)2-VD3 is a vitamin D₃ analogue. 19-Nor-22-oxa-1a,25(OH)2-VD3 has an extremely low affinity for the vitamin D receptor (VDR) and hardly binds to the vitamin D binding protein (DBP). 19-Nor-22-oxa-1a,25(OH)2-VD3 can effectively induce the differentiation of HL-60 cells and cause G₀-G₁ phase cell cycle arrest. 19-Nor-22-oxa-1a,25(OH)2-VD3 can be used to study diseases such as excessive hyperparathyroidism .
Cat. No.: HY-P84960
Synonyms: IL-3R common β chain; CDw131; Beta-C antibody; CD131 antibody; CDw131 antibody; Colony stimulating factor 2 receptor beta antibody; Colony stimulating factor 2 receptor beta Low affinity; granulocyte macrophage; antibody; Common beta chain antibody; Csf2rb antibody; Cytokine receptor common beta chain antibody; Cytokine receptor common beta chain precursor; CDw131 antigen; antibody; Cytokine receptor common subunit beta antibody; GM CSF/IL 3/IL 5 receptor common beta chain antibody; GM-CSF/IL-3/IL-5 receptor common beta subunit antibody; granulocyte-macrophage colony-stimulating factor receptor; beta antibody; IL3RB antibody; IL3RB_HUMAN antibody; IL5RB antibody; Interleukin 3 receptor; beta antibody; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta; high affinity; antibody; Interleukin 5 receptor; beta antibody; SMDP5 antibody; stimulating factor 3 receptor; beta; high affinity; antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
