1614245-70-3
Chemical Structure
Darigabat
Synonym(s): PF-06372865; CVL-865
- CAS No.: 1614245-70-3
- Formula:C22H21FN4O3S
- Molecular Weight:440.49
IUPAC Name: 7-ethyl-4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxy-[1,1'-biphenyl]-3-yl)-7H-imidazo[4,5-c]pyridazine
InChIKey: PTTQXDBPTFOCMT-UHFFFAOYSA-N
SMILES: CCN1C2=NN=CC(C(C=C3)=CC(C(C=CC([S](CC)(=O)=O)=C4)=C4OC)=C3F)=C2N=C1
Biological Activity: Darigabat (PF-06372865) is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). Darigabat is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. Darigabat can across the blood-brain barrier (BBB). Darigabat has anxiolytic activity and has the potential for epilepsy[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Darigabat | 98.99% | Darigabat (PF-06372865) is an orally active, α2/α3/α5 subtype-selective GABAA positive allosteric modulator (PAM). Darigabat is a high affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. Darigabat can across the blood-brain barrier (BBB). Darigabat has anxiolytic activity and has the potential for epilepsy. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.48
HY-133910Lu AE98134 -
Similarity Score 0.47
HY-101117REED226 (Standard) -
Similarity Score 0.47
HY-186250TRIM21 ligand-1 -
Similarity Score 0.46
HY-176708ISM5939 -
Similarity Score 0.46
HY-120232ABT-963 -
Similarity Score 0.46
HY-149863DDO-8926 -
Similarity Score 0.46
HY-177739Antifibrotic agent 2 -
Similarity Score 0.45
HY-160873Firefly luciferase-IN-5 -
Similarity Score 0.45
![4,4'-(Benzo[c][1,2,5]selenadiazole-4,7-diyl)bis(3-methoxybenzoic acid) Chemical Structure](//file.medchemexpress.com/product_pic/hy-w456583.gif)
HY-W4565834,4'-(Benzo[c][1,2,5]selenadiazole-4,7-diyl)bis(3-methoxybenzoic acid) -
Explore the MedChemAI to find more analogs
![4,4'-(Benzo[c][1,2,5]selenadiazole-4,7-diyl)bis(3-methoxybenzoic acid) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w456583.gif)
