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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
251 Results for "
brd4 protac
" in MedChemExpress (MCE) Product Catalog:
Products (251)
251 Results for "brd4 protac" in MCE Product Catalog:
Forschungsgebiete:
β-NF-JQ1 is a BRD2/3/4 PROTAC degrader. β-NF-JQ1 recruits the AhR E3 ligase complex to BRD2, BRD3 and BRD4, induces AhR-BRD interaction, and mediates AhR-dependent degradation through the proximity effect between the target protein and AhR. β-NF-JQ1 acts as an antiproliferative and cytotoxic agent that induces anticancer activity associated with BRD protein knockdown. β-NF-JQ1 can be used for research on breast cancer and neuroblastoma .
Art. -Nr.: HY-187338
Target:
Forschungsgebiete:
CRBN ligand-908 is a cereblon (CRBN) ligand and also a HaloTag-binding degrader. CRBN ligand-908 competes with fluorescent lenalidomide ligands for binding to full-length CRBN protein. CRBN ligand-908 contains a chlorohexyl group that covalently reacts with HaloTag fused to target proteins. CRBN ligand-908 induces degradation of HaloTag-fused FAK, endogenous MARC1, and BRD4 proteins. CRBN ligand-908 is a proteasome- and Cullin-dependent degrader. CRBN ligand-908 does not induce degradation of the novel CRBN substrates GSPT1, SALL4, or CSNK1α. CRBN ligand-908 can be used to synthesize PROTACs, such as HaloPROTAC 4 (HY-187337) .
Forschungsgebiete:
BET-IN-31 is a potent BET inhibitor and a ligand for target BRD4 protein for PROTACT GNE-987 (HY-129937A) .
Target:
Forschungsgebiete:
Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition .
Art. -Nr.: HY-181847
CAS. Nr.: 2785405-22-1
Target:
Forschungsgebiete:
JQ-1 (carboxylic acid)-NHS is an ester derivative of (+)-JQ-1 (HY-13030). JQ-1 (carboxylic acid)-NHS serves as a negative control .
Target:
Forschungsgebiete:
XY-06-007 is a mutation-selective PROTAC degrader targeting BRD4BD1L94V, with a DC50, 6 h of 10.2 nM in Flp293T cells. XY-06-007 recruits the E3 ligase CRL4CRBN to BRD4BD1L94V, triggering ubiquitination and proteasomal degradation. XY-06-007 can be combined with the dTAG strategy to achieve degrader-mediated synchronous depletion of the corresponding protein fusion in cells. XY-06-007 is applicable for cancer research .
Art. -Nr.: HY-181757
CAS. Nr.: 3061406-50-3
Forschungsgebiete:
DCAF11 ligand-Linker Conjugate 1 is a conjugate of a DCAF11 ligand and a linker. DCAF11 ligand-Linker Conjugate 1 can be used for the synthesis of PROTAC LGF308 (HY-181756) .
Art. -Nr.: HY-168634
Target:
Forschungsgebiete:
SJ46421 is a BRD3BD2 PROTAC degrader. SJ46421 induces a cooperative ternary complex of KLHDC2 and BRD3BD2 with an IC50 of 7.8 nM. SJ46421 binds to the substrate-binding pocket of KLHDC2, forms cooperative ternary complexes with BRD3BD2, BRD2BD2 and BRD4BD2, disrupts the autoinhibitory tetramer assembly of KLHDC2, drives selective ubiquitination of BRD3BD2, and inhibits the ubiquitination of endogenous KLHDC2 diglycine substrates. SJ46421 can be used in cancer research .
Art. -Nr.: HY-180960
CAS. Nr.: 3031840-41-9
Target:
Forschungsgebiete:
NEP202 is a SMARCA2 PROTAC degrader designed based on the GID4 E3 ligase. NEP168 can be used for cancer research .
Synonyms: 5-Azidovaleric acid
Target:
Forschungsgebiete:
5-Azidopentanoic acid (5-Azidovaleric acid) is a crosslinker/cyclization reagent as well as an azido-containing carboxylic acid. 5-Azidopentanoic acid participates in Cu I-catalyzed azide-alkyne cycloaddition reactions; when used to cap the N-terminus of resin-bound peptides containing propargylglycine residues, it enables head-to-tail cyclodimerization of peptides. 5-Azidopentanoic acid introduces azido functional groups into chitosan via amidation for strain-promoted azide-alkyne cycloaddition click reactions. 5-Azidopentanoic acid acts as an aliphatic bifunctional ligand and capping agent for CdSe tetrapods; its bromo group can be converted to an azido group, which then undergoes catalyst-free alkyne-azide cycloaddition click reactions with ethynyl-terminated poly (3-hexylthiophene) .
Art. -Nr.: HY-159579
CAS. Nr.: 3055592-99-6
Target:
Forschungsgebiete:
CW-3308 is an orally active BRD9 PROTAC degrader with an DC50 of 92 nM. CW-3308 forms a ternary complex with BRD9 and cereblon to mediate BRD9 degradation. CW-3308 inhibits the viability of synovial sarcoma and rhabdoid tumor cells. CW-3308 reduces BRD9 protein levels in xenograft tumor tissues and suppresses tumor growth in xenograft models. CW-3308 can be used for the research of synovial sarcoma and rhabdoid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
