SJ46421
SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2-BRD3 PROTAC protein degrader. SJ46421 induces cooperative ternary complexes with KLHDC2 and BRD3BD2, with an IC50 of 7.8 nM. SJ46421 selectively inhibits KLHDC2 substrate ubiquitylation. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4. SJ46421 possesses poor cell permeability.
(Pink: BRD3 BD2 ligand (HY-13030); Blue: KLHDC2 ligand (HY-168536); Black: linker (HY-20797)).
For research use only. We do not sell to patients.
- Formula: C42H41ClN8O5S2
- Molecular Weight:837.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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KLHDC2-BRD3 BD2 19 nM (Kd) |
KLHDC2-BRD4 BD2 109 nM (Kd) |
KLHDC2-BRD7 BD2 208 nM (Kd) |
BRD3 BD2 987 nM (Kd) |
BRD4 BD2 1020 nM (Kd) |
BRD2 BD2 2090 nM (Kd) |
Chemical Information
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Molecular Weight 837.41
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Formula C42H41ClN8O5S2
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SMILES
O=C(O)CNC(CC1=CSC(C2=CC=C3C=CC=C(OCCN4CCN(C(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)CC4)C3=C2)=N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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