3055592-99-6
Chemical Structure
CW-3308
- CAS No.: 3055592-99-6
- Formula:C45H48N6O8
- Molecular Weight:800.90
InChIKey: ZXEZSPAYGZVVCZ-UHFFFAOYSA-N
SMILES: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C4C(CN(CC(CC5)CCC65CCN(C(C7=C(OC)C=C(C(C8=CC=NC=C98)=CN(CC)C9=O)C=C7OC)=O)CC6)C4)=C3)=O
Biological Activity: CW-3308 is an orally active BRD9 PROTAC degrader with an DC50 of 92 nM. CW-3308 forms a ternary complex with BRD9 and cereblon to mediate BRD9 degradation. CW-3308 inhibits the viability of synovial sarcoma and rhabdoid tumor cells. CW-3308 reduces BRD9 protein levels in xenograft tumor tissues and suppresses tumor growth in xenograft models. CW-3308 can be used for the research of synovial sarcoma and rhabdoid tumors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CW-3308 | 99.43% | CW-3308 is an orally active BRD9 PROTAC degrader with an DC50 of 92 nM. CW-3308 forms a ternary complex with BRD9 and cereblon to mediate BRD9 degradation. CW-3308 inhibits the viability of synovial sarcoma and rhabdoid tumor cells. CW-3308 reduces BRD9 protein levels in xenograft tumor tissues and suppresses tumor growth in xenograft models. CW-3308 can be used for the research of synovial sarcoma and rhabdoid tumors. | ||||||||||||||||||||
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Similarity Score 0.62
HY-153367FHD-609 -
Similarity Score 0.62
HY-153632PROTAC BRD9 Degrader-6 -
Similarity Score 0.61
HY-155361PROTAC BRD9 Degrader-7 -
Similarity Score 0.59
HY-148739dBRD 9-A -
Similarity Score 0.58
HY-117690dBRD9 -
Similarity Score 0.58
HY-117690AdBRD9 dihydrochloride -
Similarity Score 0.57
HY-162651PROTAC BRD9 Degrader-8 -
Similarity Score 0.55
HY-145400PROTAC BRD9 Degrader-3 -
Similarity Score 0.53
HY-145947PROTAC BRD9 Degrader-5 -
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