dBRD9
Based on 1 Customer Validation
dBRD9,a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family.
(Pink: BRD9 ligand (HY-100351); Blue: Cereblon ligand (HY-14658); Black: linker (HY-128833)).
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 2170679-45-3
- Formula: C40H45N7O10
- Molecular Weight:783.83
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
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BRD9 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A204 | IC50 |
0.0898 μM
Compound: 21;dBRD9
|
Antiproliferative activity against human A204 cells assessed as inhibition of cell growth incubated for 7 days by CellTiterGlo assay
Antiproliferative activity against human A204 cells assessed as inhibition of cell growth incubated for 7 days by CellTiterGlo assay
|
[PMID: 30540463] |
dBRD9 (0.5-5000 nM; 4 h) reduces the expression of BRD9 with concentration-dependent manner, but has insignificant effect on the expression of actin, BRD4 and BRD7 in MOLM-13 cells[1].
dBRD9 (100 nM; 2 h) is selective for BRD9 in MOLM-13 cells[1].
dBRD9 (7 d) has anti-proliferation effect on EOL-1 and MOML-13 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM-13 cells.
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Concentration:0.5, 5, 50, 500 and 5000 nM.
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Incubation Time:4 h.
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Result:Reduced the expression of BRD9.
Chemical Information
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CAS No. 2170679-45-3
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Appearance Solid
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Molecular Weight 783.83
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Formula C40H45N7O10
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Color Light yellow to yellow
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SMILES
O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (127.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2758 mL | 6.3789 mL | 12.7579 mL | 31.8947 mL |
| 5 mM | 0.2552 mL | 1.2758 mL | 2.5516 mL | 6.3789 mL | |
| 10 mM | 0.1276 mL | 0.6379 mL | 1.2758 mL | 3.1895 mL | |
| 15 mM | 0.0851 mL | 0.4253 mL | 0.8505 mL | 2.1263 mL | |
| 20 mM | 0.0638 mL | 0.3189 mL | 0.6379 mL | 1.5947 mL | |
| 25 mM | 0.0510 mL | 0.2552 mL | 0.5103 mL | 1.2758 mL | |
| 30 mM | 0.0425 mL | 0.2126 mL | 0.4253 mL | 1.0632 mL | |
| 40 mM | 0.0319 mL | 0.1595 mL | 0.3189 mL | 0.7974 mL | |
| 50 mM | 0.0255 mL | 0.1276 mL | 0.2552 mL | 0.6379 mL | |
| 60 mM | 0.0213 mL | 0.1063 mL | 0.2126 mL | 0.5316 mL | |
| 80 mM | 0.0159 mL | 0.0797 mL | 0.1595 mL | 0.3987 mL | |
| 100 mM | 0.0128 mL | 0.0638 mL | 0.1276 mL | 0.3189 mL |
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