2. PROTAC
    Epigenetics
  3. PROTACs
    Epigenetic Reader Domain
  4. dBRD9

dBRD9 

Cat. No.: HY-117690 Purity: 99.89%
COA Handling Instructions

dBRD9 is a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family.

For research use only. We do not sell to patients.

dBRD9 Chemical Structure

dBRD9 Chemical Structure

CAS No. : 2170679-45-3

Size Price Stock Quantity
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 640 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1280 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

dBRD9 is a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family[1].

IC50 & Target[1]

BRD9

 

In Vitro

dBRD9 (0.5-5000 nM; 4 h) reduces the expression of BRD9 with concentration-dependent manner, but has insignificant effect on the expression of actin, BRD4 and BRD7 in MOLM-13 cells[1].
dBRD9 (100 nM; 2 h) is selective for BRD9 in MOLM-13 cells[1].
dBRD9 (7 d) has anti-proliferation effect on EOL-1 and MOML-13 cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MOLM-13 cells.
Concentration: 0.5, 5, 50, 500 and 5000 nM.
Incubation Time: 4 h.
Result: Reduced the expression of BRD9.
Molecular Weight

783.83

Appearance

Solid

Formula

C40H45N7O10
CAS No.
SMILES

O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (127.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2758 mL 6.3789 mL 12.7579 mL
5 mM 0.2552 mL 1.2758 mL 2.5516 mL
10 mM 0.1276 mL 0.6379 mL 1.2758 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

dBRD92170679-45-3dBRD 9dBRD-9PROTACsEpigenetic Reader DomainEOL-1MOML-13BRD9Inhibitorinhibitorinhibit

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