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Cat. No.: HY-187338

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CRBN ligand-908

CRBN ligand-908 is a cereblon (CRBN) ligand and also a HaloTag-binding degrader. CRBN ligand-908 competes with fluorescent lenalidomide ligands for binding to full-length CRBN protein. CRBN ligand-908 contains a chlorohexyl group that covalently reacts with HaloTag fused to target proteins. CRBN ligand-908 induces degradation of HaloTag-fused FAK, endogenous MARC1, and BRD4 proteins. CRBN ligand-908 is a proteasome- and Cullin-dependent degrader. CRBN ligand-908 does not induce degradation of the novel CRBN substrates GSPT1, SALL4, or CSNK1α. CRBN ligand-908 can be used to synthesize PROTACs, such as HaloPROTAC 4 (HY-187337).

For research use only. We do not sell to patients.

Formula: C₃₂H₃₉N₅O₃
Molecular Weight:541.68

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Please store the product under the recommended conditions in the Certificate of Analysis.

CRBN ligand-908 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
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Biological Activity

Description

IC₅₀ & Target

^[1]

Cereblon

All Ligands for E3 Ligase Isoforms :

In Vitro

CRBN ligand-908 (compound 14) (24 h) potently degrades FAK-HaloTag-HiBiT in A549 cells with a pDC₅₀ of 7.91 and 58.8% maximum degradation after 24 h^[1].
CRBN ligand-908 (6 h) does not degrade the CRBN neosubstrates GSPT1, SALL4, or CSNK1α in HEK293 or SK-N-DZ cells after 6 h treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 541.68
Formula C₃₂H₃₉N₅O₃
SMILES

O=C1NC(CCN1C2=CC=CC3=C2C=CN3C4CCN(CCC5CCN(C(C6=CC=C(C)C=C6)=O)CC5)CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stevens R, et al. A Systematic Direct-to-Biology Approach Identified Potent Cereblon HaloPROTACs. ACS chemical biology. 2026 Jul 17;21(7):1798-1817. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vitro
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CRBN ligand-908

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CRBN ligand-908 Related Classifications

HY-187338 Related Classifications

Bioz

Keywords

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