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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
316 Results for "
parasite,
" in MedChemExpress (MCE) Product Catalog:
Products (316)
316 Results for "parasite," in MCE Product Catalog:
Cat. No.: HY-B0537A
CAS No.: 50357-45-4
Synonyms: MP-601205 dihydrochloride
Target:
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
Target:
Cat. No.: HY-125159
CAS No.: 187865-22-1
Synonyms: PF-00520904
Derquantel, a spirocyclic anthelmintic, is a competitive, orally active nicotinic acetylcholine receptor (nAChR) antagonist. Derquantel inhibits ACh-induced depolarization with an IC50 of 0.22 μM. By selectively antagonizing nAChRs on the somatic muscles of nematodes, Derquantel causes flaccid paralysis of muscles, thereby dislodging parasites from the host's gastrointestinal tract. Derquantel is applicable to research related to Haemonchus contortus infection and Ascaris suum infection .
PI-55 is a specific cytokinin receptor inhibitor. PI-55 is structurally related to 6-benzylaminopurine (BAP) and was shown to inhibit competitively BAP binding on Arabidopsis-specific receptors CRE1/AHK4 and AHK3. PI-55 inhibits cytokinins induced haustorium formation and increased parasite aggressiveness .
Cat. No.: HY-146166
CAS No.: 1280738-47-7
Research Areas:
PT4 is a therapeutic agent against Cutaneous leishmaniasis (CL). PT4 is effective against both species of Leishmania, with IC50s of 125.18 and 233.18 μM for L. amazonensis and L. braziliensis, respectively. PT4 decreases of mitochondrial membrane potential and increases production of reactive oxygen species, which leads to parasite death. PT4 has a potent in vivo anti-inflammatory activity .
Cat. No.: HY-15308B
CAS No.: 110415-68-4
Target:
Research Areas:
Δ²-Avermectin B₁ₐ (Compound 3) is an antiparasitic agent targeting glutamate-gated chloride channels (GluCls) in the neuromuscular system of invertebrates. Δ²-Avermectin B₁ₐ enhances chloride ion influx, leading to hyperpolarization of the neuromuscular cell membrane, inhibition of neural signal transmission, and ultimately paralysis and death of parasites. Δ²-Avermectin B₁ₐ is promising for research of agricultural pests .
Cat. No.: HY-179463
CAS No.: 2332840-70-5
BKI 1708 is a potent and orally active calcium-dependent protein kinase 1 (CDPK1) inhibitor (IC50 = 0.7 nM). BKI 1708 exhibits potent activity against Neospora (IC50 = 481 nM) and Toxoplasma (IC50 = 122 nM). BKI-1708 induces the formation of multinucleated complexes. BKI-1708 efficiently inhibits vertical transmission of both parasites and increases pup survival in mice .
Cat. No.: HY-179584
Antileishmanial agent-38 (compound 197) is a host-directed small molecule antileishmanial agent exhibiting potent broad-spectrum activity against Leishmania spp. Antileishmanial agent-38 inhibits intracellular parasites primarily by targeting the host protein lysozyme, while also displaying direct activity against extracellular L. donovani promastigotes. Antileishmanial agent-38 can be used for leishmaniasis research .
Cat. No.: HY-189048
Target:
Research Areas:
CPN4F is a chalcone derivative with antiparasitic activity. CPN4F is an inhibitor of the cysteine protease cruzain. CPN4F forms a key hydrogen bond with the Trp-184 residue in the active site of parasitic cruzain as an electrophile, and induces oxidative stress, cell membrane degradation, and necrosis, thereby inhibiting parasite proliferation. CPN4F is used in research related to Chagas disease .
Cat. No.: HY-B0777R
CAS No.: 113507-06-5
Synonyms: CL301423 (Standard)
Research Areas:
Moxidectin (Standard) is the analytical standard of Moxidectin. This product is intended for research and analytical applications. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk .
Cat. No.: HY-P5344
Synonyms: Fluorigenic PEXEL peptide
Cat. No.: HY-159479
PfSUB1-IN-1 (compound 4c) is a plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1) Inhibitor (IC50: 15 nM). PfSUB1 is an antimalarial target. PfSUB1-IN-1 inhibits the growth of a genetically modified P. falciparum line expressing reduced levels of PfSUB1 13-fold more efficiently compared to a wild-type parasite line .
Cat. No.: HY-184406
Antimalarial agent 65 is an inhibitor of Plasmodium falciparum lysyl-tRNA synthetase (PfKRS1), with a pIC50 value of 6.9 against Plasmodium falciparum. Antimalarial agent 65 inhibits the growth of Plasmodium falciparum strains. Antimalarial agent 65 exhibits activity across multiple life cycle stages of the malaria parasite, including transmission-blocking activity. Antimalarial agent 65 can be used in malaria-related research .
Cat. No.: HY-B0148R
CAS No.: 105462-24-6
Synonyms: Risedronate (Standard)
Target:
Research Areas:
Risedronic acid (Standard) (Risedronate (Standard)) is the analytical standard of Risedronic acid (HY-B0148). This product is intended for research and analytical applications. Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC50 of 20.3 μM).
Target:
Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dimesylate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dimesylate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dimesylate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities .
Cat. No.: HY-DY2029
Target:
Research Areas:
Ready-to-Use Wright Staining Solution is a pre-mixed Romanowsky type absorbent composite staining agent, containing Eosin Y (HY-D0505) and methylene blue (HY-14536). Ready-to-Use Wright Staining Solution is suitable for staining of blood and cell smears, bacteria, protozoan parasites, etc., without the need for manual weighing of powder or complex preparation, thus saving time and ensuring the consistency of diagnostic results.
Cat. No.: HY-N10534
CAS No.: 71208-06-5
Synonyms: Lewis X
Category:
Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides Cancer
Target:
Cat. No.: HY-P2209
CAS No.: 53947-96-9
Synonyms: Daechuine S27; N-Demethylamphibine H
Category:
Alkaloids Other Alkaloids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae
Target:
Cat. No.: HY-W197328
CAS No.: 2241017-37-6
Isonicotinaldehyde 2-pyridin is an antileishmanial agent that is effective against the promastigotes of L. amazonensis and L. braziliensis. Isonicotinaldehyde 2-pyridin has no significant toxic effects on mouse macrophages. The biological activity of Isonicotinaldehyde 2-pyridin is closely related to increasing reactive oxygen species (ROS) and interfering with parasite mitochondrial function. Isonicotinaldehyde 2-pyridin showed its effects on L. amazonensis in preliminary studies on its pharmacological mechanism of action .
Cat. No.: HY-111759R
CAS No.: 22242-96-2
Synonyms: 7-CN-7-C-Ino (Standard)
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
