303 Results for "

chronic obstructive

" in MedChemExpress (MCE) Product Catalog:
Products (303)

303 Results for "chronic obstructive" in MCE Product Catalog:

Lomasemtiv
Lomasemtiv
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Art. -Nr.: HY-184098
CAS. Nr.: 2770252-94-1
Synonyms: Lomasemtivum
Target:  

Calcium Channel

Forschungsgebiete:  

Neurological Disease

Lomasemtiv (Lomasemtivum) is a Troponin activator. Lomasemtiv activates skeletal muscle myofibrils. Lomasemtiv is applicable to sarcopenia research .
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Isorhapontigenin (Standard)
Isorhapontigenin (Standard)
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Art. -Nr.: HY-N2593R
CAS. Nr.: 32507-66-7
Category:  

Stilbenes Gnetum cleistostachyum C. Y. Cheng Gnetaceae Phenols Polyphenols Plants

Target:  

Reference Standards Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin (Standard) is the analytical standard of Isorhapontigenin (HY-N2593). This product is intended for research and analytical applications. Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes.
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GIPR antagonist 2
GIPR antagonist 2
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Art. -Nr.: HY-186050
CAS. Nr.: 3105300-99-7
Target:  

Insulin Receptor

Forschungsgebiete:  

Metabolic Disease

GIPR antagonist 2 is a glucose-dependent insulinotropic polypeptide receptor (GIPR) antagonist with an IC50 of 7.2 nM in CHO-K1 cells. GIPR antagonist 2 can be used in research related to diseases such as obesity, type 2 diabetes, non-alcoholic fatty liver disease, and atherosclerosis .
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