GIPR antagonist 2
Based on 1 Customer Validation
GIPR antagonist 2 is a glucose-dependent insulinotropic polypeptide receptor (GIPR) antagonist with an IC50 of 7.2 nM in CHO-K1 cells. GIPR antagonist 2 can be used in research related to diseases such as obesity, type 2 diabetes, non-alcoholic fatty liver disease, and atherosclerosis.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 3105300-99-7
- Formula: C24H25F2N5O3
- Molecular Weight:469.48
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
GIPR 7.2 nM (IC50) |
In Vitro
GIPR antagonist 2 (Example 14) effectively inhibits the GIPR-mediated cAMP signaling pathway in CHO-K1 cells, with an IC50 of 7.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3105300-99-7
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Appearance Solid
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Molecular Weight 469.48
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Formula C24H25F2N5O3
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Color White to off-white
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SMILES
FC1=C(O)C(F)=CC(N2N=C(C=C2)NC([C@@H]3N(CCC3)C(NC4=CC=C(C=C4)C(C)C)=O)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (106.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1300 mL | 10.6501 mL | 21.3002 mL | 53.2504 mL |
| 5 mM | 0.4260 mL | 2.1300 mL | 4.2600 mL | 10.6501 mL | |
| 10 mM | 0.2130 mL | 1.0650 mL | 2.1300 mL | 5.3250 mL | |
| 15 mM | 0.1420 mL | 0.7100 mL | 1.4200 mL | 3.5500 mL | |
| 20 mM | 0.1065 mL | 0.5325 mL | 1.0650 mL | 2.6625 mL | |
| 25 mM | 0.0852 mL | 0.4260 mL | 0.8520 mL | 2.1300 mL | |
| 30 mM | 0.0710 mL | 0.3550 mL | 0.7100 mL | 1.7750 mL | |
| 40 mM | 0.0533 mL | 0.2663 mL | 0.5325 mL | 1.3313 mL | |
| 50 mM | 0.0426 mL | 0.2130 mL | 0.4260 mL | 1.0650 mL | |
| 60 mM | 0.0355 mL | 0.1775 mL | 0.3550 mL | 0.8875 mL | |
| 80 mM | 0.0266 mL | 0.1331 mL | 0.2663 mL | 0.6656 mL | |
| 100 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5325 mL |
GIPR antagonist 2 Related Classifications
HY-186050 Related Classifications
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Keywords
- GIPR antagonist 2
- 3105300-99-7
- GIPR antagonist2
- GIPR antagonist-2
- Insulin Receptor
- type 2 diabetes mellitus
- heart failure
- nonalcoholic fatty liver disease
- obstructive sleep apnea
- chronic kidney disease
- obesity
- atherosclerosis
- glucose-dependent insulinotropic polypeptide receptor
- peripheral arterial disease
- nonalcoholic steatohepatitis
- Inhibitor
- inhibitor
- inhibit