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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3466 Results for "
Prothrombin complex concentrate
" in MedChemExpress (MCE) Product Catalog:
Products (3466)
3466 Results for "Prothrombin complex concentrate" in MCE Product Catalog:
Cat. No.: HY-P811903A
Synonyms: RMND5A; Required For Meiotic Nuclear Division 5 Homolog A; P44CTLH; GID2A; RMD5; GID2; E3 Ubiquitin-Protein Transferase RMND5A; 44-KD Protein Coding For CTLH Motif; GID complex Subunit 2 Homolog A; Protein RMD5 Homolog A; FLJ13910; Required For Meiotic Nuclear Division 5 Homolog A (S. Cerevisiae); C-Terminal To LisH Motif, 44 KDa; EC 2.3.2.27; CTLH
Cat. No.: HY-128795
CAS No.: 2095304-61-1
Research Areas:
KH176m is the major active metabolite of KH176 (HY-121577). KH176m is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor that can cross the blood-brain barrier, with an IC50 of 0.16 µM against mouse mPGES-1 and 1.51 µM against human mPGES-1. KH176m blocks LPS- or IL-1β-induced PGE2 production, scavenges ROS, inhibits lipid peroxidation, accelerates NADPH consumption, suppresses the growth of prostate cancer spheroids, reduces the CD44 + CD24 − prostate cancer stem cell population, and protects fibroblasts with oxidative phosphorylation defects from redox stress-induced death. KH176m can be used in research related to mitochondrial diseases, inflammatory pain, inflammatory neurological diseases, inflammatory cancers, and prostate cancer .
Target:
Research Areas:
I-XW-053 is a specific anti-HIV-1 capsid inhibitor (IC50=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (Kd=66.3 μM), I-XW-053 disrupts capsid function and reduces polymerization levels. I-XW-053 effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 can be widely used in studies related to HIV-1 infection .
Cat. No.: HY-186271
CAS No.: 2148927-98-2
Target:
Research Areas:
TLR4 agonist-2 is a TLR4 agonist with EC50 values of 0.82 μM and 0.43 μM for mTLR4 and hTLR4, respectively. TLR4 agonist-2 induces the production of TLR4-dependent cytokines and chemokines. TLR4 agonist-2 can be used for immunological research .
Cat. No.: HY-P80984
Synonyms: CK-5; CK5; Cytokeratin-5; Cytokeratin5; DDD; DDD1; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K2C5_HUMAN; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); Keratin 5; Keratin ; keratin complex 2, basic, gene 5; keratin, type II cytoskeletal 5 ; Keratin-5; Keratin5; KRT 5; Krt5; KRT5A; type II cytoskeletal 5 ; Type-II keratin Kb5;
Cat. No.: HY-P83701
Synonyms: HLA class I histocompatibility antigen E alpha chain antibody;
EA1.2 antibody;
EA2.1 antibody;
HLA 6.2 antibody;
HLA class I histocompatibility antigen alpha chain E antibody;
HLA class I histocompatibility antigen E alpha chain precursor antibody;
HLA class I histocompatibility antigen E alpha chain precursor antibody;
HLA6.2 antibody;
HLAE antibody;
Lymphocyte antigen antibody;
Major histocompatibility complex class I E antibody;
MHC antibody;
MHC class I antigen E antibody;
MHC HLA E alpha 1 antibody;
MHC HLA E alpha 2.1 antibody;
QA1 antibody;
Cat. No.: HY-P812022
Synonyms: MTREX; Mtr4 Exosome RNA Helicase; KIAA0052; FSAP118; SKIV2L2; Mtr4; Dob1; Functional Spliceosome-Associated Protein 118; Superkiller Viralicidic Activity 2-Like 2; ATP-Dependent RNA Helicase SKIV2L2; ATP-Dependent RNA Helicase DOB1; TRAMP-Like complex Helicase; Exosome RNA Helicase MTR4; Ski2 Like RNA Helicase 2; Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae); ATP-Dependent Helicase SKIV2L2; EC 3.6.4.13; EC 3.6.1; DOB1; MTR4
Cat. No.: HY-P812022A
Synonyms: MTREX; Mtr4 Exosome RNA Helicase; KIAA0052; FSAP118; SKIV2L2; Mtr4; Dob1; Functional Spliceosome-Associated Protein 118; Superkiller Viralicidic Activity 2-Like 2; ATP-Dependent RNA Helicase SKIV2L2; ATP-Dependent RNA Helicase DOB1; TRAMP-Like complex Helicase; Exosome RNA Helicase MTR4; Ski2 Like RNA Helicase 2; Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae); ATP-Dependent Helicase SKIV2L2; EC 3.6.4.13; EC 3.6.1; DOB1; MTR4
Cat. No.: HY-P86889
Synonyms: Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody; Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody; GPSA antibody; Gs alpha subunit antibody; GSA antibody; GSP antibody; Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1 antibody; Guanine nucleotide binding protein alpha stimulating activity polypeptide 1 antibody; Guanine nucleotide binding protein G(s) subunit alpha isoforms short antibody; Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas antibody; Guanine nucleotide regulatory protein antibody; MGC33735 antibody; NESP antibody; NESP55 antibody; Neuroendocrine secretory protein antibody; PHP1A antibody; PHP1B antibody; PHP1C antibody; POH antibody; Protein ALEX antibody; Protein GNAS antibody; Protein NESP55 antibody; SCG6 antibody; Secretogranin VI antibody; XLalphas antibody; XLas antibody;
Cat. No.: HY-P73138
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGFBP3; Binding Protein 53; Insulin Like Growth Factor Binding Protein 3; Binding Protein 29; IBP3; IGFBP-3; Insulin-Like Growth Factor-Binding Protein 3; IBP-3; IGF-Binding Protein 3; CDNA FLJ43234 Fis, Clone HCHON2002964, Highly Similar To Insulin-Like Growth Factor-Binding Protein 3; BP-53; Insulin-Like Growth Factor Binding Protein 3, Isoform CRA_b; Acid Stable Subunit Of The 140 K IGF complex; Insulin-Like Growth Factor Binding Protein 3; Growth Hormone-Dependent Binding Protein
Species:
Human
Source:
HEK293
Cat. No.: HY-P80243
Synonyms: cytoplasmic 1 antibody;
MGC138448 antibody;
NF ATc antibody;
NF ATc1 antibody;
NF-ATc antibody;
NF-ATc1 antibody;
NF-ATc1.2 antibody;
NFAC1_HUMAN antibody;
NFAT 2 antibody;
NFAT transcription complex cytosolic component antibody;
NFATC 1 antibody;
NFATc antibody;
NFATc1 antibody;
Nuclear factor of activated T cells cytoplasmic 1 antibody;
Nuclear factor of activated T cells cytoplasmic calcineurin dependent 1 antibody;
Nuclear factor of activated T cells cytosolic component 1 antibody;
nuclear factor of activated T-cells 'c' antibody;
Nuclear factor of activated T-cells antibody
Cat. No.: HY-P811931
Synonyms: CHCHD6; Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6; CHCM1; PPP1R23; MICOS25; Mic25; Mitochondrial Contact Site And Cristae Organizing System Subunit 25; Coiled-Coil-Helix Cristae Morphology Protein 1; Protein Phosphatase 1, Regulatory Subunit 23; MICOS complex Subunit MIC25; MGC13016; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6, Mitochondrial; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6; Coiled-Coil-Helix Cristae Morphology 1; Coiled Coil Helix Cristae Morphology 1; MIC25
Cat. No.: HY-P811931A
Synonyms: CHCHD6; Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6; CHCM1; PPP1R23; MICOS25; Mic25; Mitochondrial Contact Site And Cristae Organizing System Subunit 25; Coiled-Coil-Helix Cristae Morphology Protein 1; Protein Phosphatase 1, Regulatory Subunit 23; MICOS complex Subunit MIC25; MGC13016; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6, Mitochondrial; Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6; Coiled-Coil-Helix Cristae Morphology 1; Coiled Coil Helix Cristae Morphology 1; MIC25
Cat. No.: HY-P86790
Synonyms: BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; Breast Cancer 2 tumor suppressor antibody; Breast cancer susceptibility protein BRCA2 antibody; Breast cancer type 2 susceptibility protein antibody; BROVCA2 antibody; FACD antibody; FAD 1 antibody; FAD antibody; FAD1 antibody; FANCB antibody; FANCD 1 antibody; FANCD antibody; FANCD1 antibody; FANCD1 gene antibody; Fanconi anemia complementation group D1 antibody; Fanconi anemia group D1 protein antibody; GLM3 antibody; mutant BRCA2 antibody; OTTHUMP00000018803 antibody; OTTHUMP00000042401 antibody; PNCA2 antibody; XRCC11 antibody;
Cat. No.: HY-P86957
Synonyms: CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 complex antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 complex antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; Methyl CpG binding protein splice variant 1 antibody; Methyl CpG binding protein splice variant 2 antibody; Methyl CpG binding protein splice variant 3 antibody; Methyl CpG binding protein splice variant 4 antibody; Methyl-CpG-binding domain protein 1 antibody; Methyl-CpG-binding protein MBD1 antibody; PCM 1 antibody; PCM1 antibody; Protein containing methyl-CpG-binding domain 1 antibody; Regulator of fibroblast growth factor 2 (FGF 2) transcription antibody; RFT antibody; The regulator of fibroblast growth factor 2(FGF 2) transcription antibody;
Cat. No.: HY-P83719
Synonyms: DKFZp459C139 antibody;
EC 3.4.25.1 antibody;
LMPX antibody;
Macropain epsilon chain antibody;
MB1 antibody;
MGC104214 antibody;
MGC118075 antibody;
MGC134464 antibody;
Multicatalytic endopeptidase complex epsilon chain antibody;
Proteasome (prosome, macropain) subunit, beta type, 5 antibody;
Proteasome beta 5 subunit antibody;
Proteasome catalytic subunit 3 antibody;
Proteasome chain 6 antibody;
Proteasome epsilon chain antibody;
Proteasome subunit beta type-5 antibody;
Proteasome subunit MB1 antibody;
Proteasome subunit X antibody;
Proteasome subunit, beta type, 5 antibody;
Proteasome subunit, beta-5 antibody;
PSB5_HUMAN antibody;
PSMB5 antibody;
PSX large multifunctional protease X antibody;
X antibody
Cat. No.: HY-42163S
Target:
Research Areas:
3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-Bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-(tosylmethyl)te trahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol-d3 It is a deuterated substance. 3-((2S,5S)-5-(2-((2S,4R,6R)-6-(((2S,3S,4R,5R)-5-((S)-2,3-Bis((tert-butyldimethylsilyl)oxy)propyl)-4-methoxy-3-(tosylmethyl)tetrahydrofuran-2-yl)methyl)-4-methyl-5-methylenetetrahydro-2H-pyran-2-yl)ethyl)-4-methylenetetrahydrofuran-2-yl)propan-1-ol is a complex organic molecule and a high-order synthetic intermediate.
Cat. No.: HY-180419
CAS No.: 1883721-73-0
Research Areas:
SF-3-030 is a potent, selective and non-ATP competitive ERK1/2 inhibitor. SF-3-030 selectively induces apoptosis in melanoma cells containing mutated BRaf and constitutively active ERK1/2 signalling. SF-3-030 mitigates multiple features of asthma in a murine model of asthma. SF-3-030 can be used for the research of asthma and melanomasup .
Cat. No.: HY-L944
11028 compounds
MCE 18 stands for Medicinal Chemistry Evolution 2018. This metric was established based on structural data of 28,161 patented lead molecules, 1,370 marketed innovative drugs, and nearly 30,000 investigational candidates from preclinical to Phase III stages across 23 major global pharmaceutical companies from 1950 to 2018. After scaffold clustering analysis, a scoring model was constructed by integrating five three dimensional scaffold characteristics, including aromatic rings (AR), non aromatic heterocycles (NAR), chiral centers (CHIRAL), spirocycles (SPIRO), and the sp³ carbon ratio in cyclic and acyclic moieties, enabling quantitative assessment of molecular scaffold novelty and three dimensional complexity.
According to the score distribution of patented molecules, the top 25% of the original patent dataset was defined as the high novelty region. MCE 18 high scoring compounds selected based on this criterion can effectively avoid scaffold patent conflicts and intellectual property risks from the source. Molecules in this range typically feature a high sp³ carbon ratio, abundant chiral centers, spirocycles, and fused heterocycles with prominent three dimensional conformations. Their spatial properties allow precise matching to complex non traditional undruggable target pockets such as PPI interfaces and allosteric sites, making them ideal structural types for early stage screening of First in class drugs.
MCE‑18 Novelty Focused drug‑Like library strictly selects molecules from the aforementioned high scoring range, containing more than 10,000 premium drug like molecules with highly diverse scaffolds and rich 3D diversity. It can be used for high throughput screening of well established targets such as kinases, GPCRs, and proteases, and is especially suitable for hit identification in allosteric modulation, protein–protein interactions, and various undruggable orphan targets, fully supporting early stage drug discovery for cutting edge innovat
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
