MBD1 Antibody (YA6650)

MBD1 Antibody (YA6650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBD1.

Predicted band size: 70 kDa;

Q9Z2E2

17190 [NCBI]

Shipping with blue ice.

Function：Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters

Subcellular Localization：Nucleus,Nucleus matrix,Nucleus speckle,Chromosome

Expression：
Tissue_Specificity: Highly expressed in kidney, liver and brain. Detected at lower levels in heart, lung, skeletal muscle, spleen and testis

Isoforms & Post-Translational Modification：Q9Z2E2 has 5 isomers: Q9Z2E2-1: 70023 Da (predicted); Q9Z2E2-2: 64124 Da (predicted); Q9Z2E2-3: 62725 Da (predicted); Q9Z2E2-4: 63475 Da (predicted); Q9Z2E2-5: 62076 Da (predicted).
Sumoylated, sumoylation may increase interaction with ATF7IP

Subunit：Interacts with OASL, ATF7IP, ATF7IP2 and BAHD1

CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 COMPLEX antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 COMPLEX antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; Methyl CpG binding protein splice variant 1 antibody; Methyl CpG binding protein splice variant 2 antibody; Methyl CpG binding protein splice variant 3 antibody; Methyl CpG binding protein splice variant 4 antibody; Methyl-CpG-binding domain protein 1 antibody; Methyl-CpG-binding protein MBD1 antibody; PCM 1 antibody; PCM1 antibody; Protein containing methyl-CpG-binding domain 1 antibody; Regulator of fibroblast growth factor 2 (FGF 2) transcription antibody; RFT antibody; The regulator of fibroblast growth factor 2(FGF 2) transcription antibody;