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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
351 Results for "
sarcoma
" in MedChemExpress (MCE) Product Catalog:
Products (351)
351 Results for "sarcoma" in MCE Product Catalog:
Cat. No.: HY-L260
82 compounds
KRAS (Kirsten Rat Sarcoma Viral Oncogene Homolog) is one of the most important oncogenic driver genes in oncology, with high mutation frequencies in pancreatic cancer, non‑small cell lung cancer, and colorectal cancer. For a long time, KRAS was considered "undruggable" due to the lack of suitable small‑molecule binding pockets on its protein surface. In recent years, with the discovery of the switch‑II pocket and the successful approval of KRAS G12C inhibitors, KRAS‑targeted research has achieved groundbreaking progress, which has also spurred a wave of development targeting non‑G12C mutants such as G12D and G12V, as well as upstream and downstream regulatory factors including SOS1 and SHP2.
MCE KRAS Targeted Compound Library contains 82 small‑molecule compounds targeting the KRAS, serving as high‑quality research tools for mechanistic studies of KRAS‑mutant tumors, combination therapy development, resistance mechanism exploration, and high‑throughput drug screening, thereby providing robust support for KRAS‑targeted drug discovery.
Cat. No.: HY-P705880
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ROS1; Proto-Oncogene C-Ros-1; ROS Proto-Oncogene 1, Receptor Tyrosine Kinase; V-Ros UR2 sarcoma Virus Oncogene Homolog 1 (Avian); MCF3; ROS Proto-Oncogene 1 , Receptor Tyrosine Kinase; ROS; Transmembrane Tyrosine-Specific Protein Kinase; C-Ros-1; Receptor
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-N7695
CAS No.: 23133-56-4
Cat. No.: HY-145514R
CAS No.: 2624313-15-9
Target:
Research Areas:
dTAGV-1 TFA (Standard) is the analytical standard of dTAGV-1 TFA (HY-145514). This product is intended for research and analytical applications. dTAGV-1 TFA is a selective FKBP12 F36V PORTAC degrader. dTAGV-1 TFA induces rapid degradation of FKBP12 F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 TFA is applicable to functional validation studies of cancer and undegradable oncoproteins .
Cat. No.: HY-186196
CAS No.: 3095435-04-1
Research Areas:
Fentomycin-1 is a ferroptosis inducer. Fentomycin-1 activates lysosomal iron 2+ under acidic conditions with hydrogen peroxide to form a reactive iron-oxo species, which induces oxidative degradation, oxidation, and lipolysis of membrane phospholipids, triggering ferroptosis. Fentomycin-1 can be used for the research of pancreatic ductal adenocarcinoma, breast cancer metastasis, and melanoma .
Cat. No.: HY-N0566
CAS No.: 85999-40-2
Synonyms: Anemosapogenin
Cat. No.: HY-N0566R
CAS No.: 85999-40-2
Synonyms: Anemosapogenin (Standard)
Category:
Cat. No.: HY-184508
Target:
Research Areas:
E3 ligase Ligand 81 is a VHL E3 ubiquitin ligase ligand and constitutes the VHL ligand moiety of R4VPL3-1 (HY-184506). R4VPL3-1 is a PROTAC-like bifunctional degrader linking RNF4 and VHL; it binds to and modifies GPX4, thereby inhibiting its anti-ferroptotic function. R4VPL3-1 induces iron-dependent lipid peroxidation and rapid ferroptosis-mediated cell death in cancer cells. E3 ligase Ligand 81 can be used in research related to targeted protein degradation and tumors such as melanoma .
Cat. No.: HY-126778
CAS No.: 15228-71-4
Synonyms: Leurosidine
Target:
Research Areas:
Silatrane is a functionalized reagent. Silatrane stimulates the biosynthesis of DNA and proteins. Silatrane functionalizes oligonucleotides. Silatrane is applicable to the finishing of glass fibers. Silatrane can be used in research related to malignant tumors .
Cat. No.: HY-P87054
Synonyms: c ros 1 antibody; c ros antibody; c ros oncogene 1 receptor tyrosine kinase antibody; c Ros receptor tyrosine kinase antibody; c ros1 antibody; MCF 3 antibody; MCF3 antibody; Oncogene ROS antibody; OTTHUMP00000017814 antibody; OTTHUMP00000017815 antibody; c ros 1 antibody; c ros antibody; c ros oncogene 1 receptor tyrosine kinase antibody; c Ros receptor tyrosine kinase antibody; c ros1 antibody; MCF 3 antibody; MCF3 antibody; Oncogene ROS antibody; OTTHUMP00000017814 antibody; OTTHUMP00000017815 antibody; OTTHUMP00000040389 antibody; Proto oncogene c ros 1 protein antibody; Proto oncogene c Ros antibody; Proto oncogene tyrosine protein kinase ROS antibody; Proto oncogene tyrosine protein kinase ROS precursor antibody; Proto-oncogene c-Ros-1 antibody; Proto-oncogene tyrosine-protein kinase ROS antibody; Receptor tyrosine kinase c ros oncogene 1 antibody; Ros 1 antibody; ROS 1C antibody; ROS antibody; ROS proto oncogene 1 , receptor tyrosine kinase antibody; ROS_HUMAN antibody; ROS1 antibody; ROS1C antibody; Transmembrane tyrosine specific protein kinase antibody; v ros avian UR2 sarcoma virus oncogene homolog 1 antibody; v ros UR2 sarcoma virus oncogene homolog 1 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
