3095435-04-1
Chemical Structure
Fentomycin-1
- CAS No.: 3095435-04-1
- Formula:C56H66N8O6
- Molecular Weight:947.17
InChIKey: ONBUYTXHPCUCBF-ZVEWGYCRSA-N
SMILES: O=C(C1=C(C2=C(C=C(C=C2)C)C=C1)C3=O)C4=C3C=CC5=C4N[C@@]6(C)C(OC(CCC(NCCCCNC7=CC=NC(CN8CCC[C@H]8[C@@H]9CCCN9CC%10=CC(N(C)C)=CC=N%10)=C7)=O)=O)[C@H](C)O[C@]5([H])C6
Biological Activity: Fentomycin-1 is a ferroptosis inducer. Fentomycin-1 activates lysosomal iron2+ under acidic conditions with hydrogen peroxide to form a reactive iron-oxo species, which induces oxidative degradation, oxidation, and lipolysis of membrane phospholipids, triggering ferroptosis. Fentomycin-1 can be used for the research of pancreatic ductal adenocarcinoma, breast cancer metastasis, and melanoma[1][2][3].
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Fentomycin-1 | Fentomycin-1 is a ferroptosis inducer. Fentomycin-1 activates lysosomal iron2+ under acidic conditions with hydrogen peroxide to form a reactive iron-oxo species, which induces oxidative degradation, oxidation, and lipolysis of membrane phospholipids, triggering ferroptosis. Fentomycin-1 can be used for the research of pancreatic ductal adenocarcinoma, breast cancer metastasis, and melanoma. | |||||||||||||||||||||
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- [1]. Cañeque T, et al. Activation of lysosomal iron triggers ferroptosis in cancer. Nature. 2025;642(8067):492-500. [Content Brief]
- [2]. Ali Boubacar K, et al. Regulation of ferroptosis by BAP1. Cell Death Differ. 2026 Jan 23. [Content Brief]
- [3]. Palma M, et al. Lymph node environment drives FSP1 targetability in metastasizing melanoma. Nature. 2026;649(8096):477-486. [Content Brief]
Keywords
