dTAGV-1 TFA (Standard)
dTAGV-1 TFA (Standard) is the analytical standard of dTAGV-1 TFA (HY-145514). This product is intended for research and analytical applications. dTAGV-1 TFA is a selective FKBP12F36V PROTAC degrader. dTAGV-1 TFA induces rapid degradation of FKBP12F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 TFA is applicable to functional validation studies of cancer and undegradable oncoproteins.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2624313-15-9
- 分子式: C70H91F3N6O16S
- 分子量:1361.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 2624313-15-9
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分子量 1361.56
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分子式 C70H91F3N6O16S
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SMILES
OC(C(F)(F)F)=O.O=C([C@H]1N(CCCC1)C([C@H](C2=CC(OC)=C(C(OC)=C2)OC)CC)=O)O[C@@H](C3=C(C=CC=C3)OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)CCC7=CC(OC)=C(C=C7)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Nabet B, et al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nature communications. 2020 Sep 18;11(1):4687. [Content Brief]
[2]. Zhu J, et al. FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation. Science advances. 2025 Nov 28;11(48):eadz2345. [Content Brief]
[3]. Prindle V, et al. Synthetic lethality of mRNA quality control complexes in cancer. Nature. 2025 Feb;638(8052):1095-1103. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
dTAGV-1 TFA (Standard) 関連分類
HY-145514R 関連分類
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Keywords
- dTAGV-1 TFA (Standard)
- 2624313-15-9
- Reference Standards
- PROTACs
- FKBP
- PROTAC
- FK506-binding protein
- pancreatic ductal adenocarcinoma
- wild-type FKBP12
- PATU-8902 cells
- mice
- proteasome
- FKBP12F36V-tagged proteins
- pancreatic cancer
- 293FT cells
- von Hippel-Lindau (VHL) TFA E3 ubiquitin ligase complex
- Ewing sarcoma
- Inhibitor
- inhibitor
- inhibit