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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
351 Results for "
sarcoma
" in MedChemExpress (MCE) Product Catalog:
Products (351)
351 Results for "sarcoma" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N2542
CAS No.: 115810-13-4
Category:
Triterpenes Terpenoids Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields Inflammation/Immunology
Target:
2
2 Cited Publications
Cat. No.: HY-P80619
Synonyms: KIT; SCFR; Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117
2
2 Cited Publications
PROTAC K-Ras Degrader-1 is a K-Ras PROTAC degrader. It binds to both K-Ras and the Cereblon E3 ubiquitin ligase, bringing K-Ras into proximity with the ligase, thereby achieving its degradation and inhibition. PROTAC K-Ras Degrader-1 can be used for research in various cancers .
1
Target:
Research Areas:
Ulefnersen (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen can be used in the research of Amyotrophic Lateral Sclerosis (ALS) .
1
1 Cited Publications
Cat. No.: HY-P10284
CAS No.: 853248-13-2
Target:
Research Areas:
1
1 Cited Publications
Synonyms: ION-363 sodium
Target:
Research Areas:
Ulefnersen sodium (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen sodium can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen sodium can be used in the research of Amyotrophic Lateral Sclerosis (ALS) .
1
1 Cited Publications
MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC .
1
1 Cited Publications
Target:
Research Areas:
FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin (HY-17394). FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers .
1
1 Cited Publications
Research Areas:
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-targeting PROTAC molecule. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine not only targets the ubiquitination and degradation of Smad3, but also elevates the protein level of HIF-α, thereby exerting multi-pathway anti-fibrotic and renoprotective effects. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can be used in a wide range of tumor studies including cancers with KRAS inhibitor resistance, covering pancreatic ductal adenocarcinoma, acute myeloid leukemia, and various soft tissue sarcomas (such as fibrosarcoma, liposarcoma, chondrosarcoma, etc.). (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can also be applied to research related to various solid tumors and hematological malignancies, involving multiple cancer types such as colon cancer, breast cancer, ovarian cancer, non-small cell lung cancer, glioblastoma, and melanoma .
1
1 Cited Publications
Cat. No.: HY-N6015
CAS No.: 178064-13-6
Category:
Triterpenes Terpenoids Scrophulariaceae Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Cancer
Target:
1
1
1
Category:
Flavonols other families Flavonoids Monophenols Phenols Plants Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Cat. No.: HY-P73919
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HRAS; C-Has/Bas P21 Protein; Prev. HRAS1; P21 Protein; V-Ha-Ras Harvey Rat sarcoma Viral Oncogene Homolog; C-HA-RAS1; Harvey Rat sarcoma Viral Oncogene Homolog; C-BAS/HAS; Transforming Protein P21; H-RASIDX; GTPase HRas; C-H-RAS; P21ras; H-Ras-1; Ras Fami
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P701321
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SRC; Tyrosine Kinase Pp60c-Src; Prev. SRC1; P60-Src; C-Src; Protooncogene SRC, Rous sarcoma; ASV; Tyrosine-Protein Kinase SRC-1; V-Src Avian sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog; Pp60c-Src; Proto-Oncogene Tyrosine-Protein Kinase Src; THC6; SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase; Proto-Oncogene C-Src
Species:
Human
Source:
E. coli
1
Category:
Cardiovascular Disease Neurological Disease Plants Infection Alkaloids Capsicum annuum L. Other Alkaloids Solanaceae Disease Research Fields Inflammation/Immunology
Target:
1
1
1 Cited Publications
Cat. No.: HY-P72948
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSF1R; CSF-1R; Prev. FMS; Macrophage Colony Stimulating Factor I Receptor; C-FMS; Colony Stimulating Factor Receptor; CD115; Receptor Protein-Tyrosine Kinase; CSFR; FMS Proto-Oncogene; McDonough Feline sarcoma Viral (V-Fms) Oncogene Homolog; BANDDOS; Macr
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P73486
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: YES1; YES Proto-Oncogene 1; Src Family Tyrosine Kinase; HsT441; C-Yes; Yes; V-Yes-1 Yamaguchi sarcoma Viral Oncogene Homolog 1; Tyrosine-Protein Kinase Yes; Proto-Oncogene C-Yes; YES1 Proto-Oncogene; Src Family Tyrosine Kinase; Proto-Oncogene Tyrosine-Pro
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
MS-L6 is a OXPHOS inhibitor and antimalarial agent. MS-L6 inhibits NADH oxidation and electron transport. MS-L6 induces OXPHOS uncoupling, dissipates mitochondrial membrane potential, increases non-ATP-coupled oxygen consumption, and reduces ATP synthesis. MS-L6 triggers the production of ROS. MS-L6 exhibits anti-amoebic activity. MS-L6 exerts antitumor activity in mouse lymphoma xenograft models. MS-L6 can be used in research related to B-cell lymphoma, T-cell lymphoma, and non-Hodgkin B-cell lymphoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
