15228-71-4
Chemical Structure
Vinrosidine
Synonym(s): Leurosidine
- CAS No.: 15228-71-4
- Formula:C46H58N4O9
- Molecular Weight:810.97
IUPAC Name: methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((3R,5R,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate
InChIKey: JXLYSJRDGCGARV-KSNABSRWSA-N
SMILES: CC[C@@]12[C@@]3([H])[C@]4(CCN3CC=C2)[C@](N(C5=CC(OC)=C([C@@]6(C7=C(CC[N@@]8C[C@](C[C@@](O)(C8)CC)([H])C6)C9=CC=CC=C9N7)C(OC)=O)C=C54)C)([H])[C@](O)([C@@H]1OC(C)=O)C(OC)=O
Biological Activity: Vinrosidine (Leurosidine) is a mitotic spindle microtubule inhibitor with antitumor activity. Vinrosidine regulates tubulin dynamics at microtubule plus ends, disrupts mitotic spindle function, and blocks cell cycle progression at metaphase. Vinrosidine exhibits antitumor activity in multiple in vivo xenograft models. Vinrosidine can be used in cancer-related research[1][2].
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Vinrosidine | Vinrosidine (Leurosidine) is a mitotic spindle microtubule inhibitor with antitumor activity. Vinrosidine regulates tubulin dynamics at microtubule plus ends, disrupts mitotic spindle function, and blocks cell cycle progression at metaphase. Vinrosidine exhibits antitumor activity in multiple in vivo xenograft models. Vinrosidine can be used in cancer-related research. | |||||||||||||||||||||
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