134 Results for "

IMP

" in MedChemExpress (MCE) Product Catalog:
Products (134)

134 Results for "IMP" in MCE Product Catalog:

Cat. No.: HY-P99027
CAS No.: 2137049-37-5
Synonyms: LAG525; IMP701; Hu5A8

Target:  

LAG-3

Research Areas:  

Cancer

Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules. Ieramilimab restores T-cell and NK-cell-mediated antileukemic immunity by reducing exhaustion and augmenting cytokine output and cytotoxicity. Ieramilimab increases the infiltration of cytotoxic T lymphocytes and reduces baseline densities of regulatory T cells (Tregs) and ADAM10-expressing tumor cells. Ieramilimab can be used for the study of various malignancies including melanoma, RCC, and advanced solid tumors .
loading...
    loading...
Cat. No.: HY-136498A
CAS No.: 2096342-42-4
Purity:  95.34%
Target:  

Drug Metabolite

Research Areas:  

Infection

T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .
loading...
    loading...
Cat. No.: HY-W717548
CAS No.: 1160513-60-9
Target:  

Drug Metabolite

Research Areas:  

Others

Safinamide acid (Compound Imp-E) is the metabolite of Safinamide (HY-70057). Safinamide acid can be formed by hydrolysis of Safinamide intermediate under alkaline or acidic conditions. Safinamide acid is utilized to monitor process-related impurities and degradation products in safinamide samples .
loading...
    loading...
Cat. No.: HY-161712
CAS No.: 2427862-70-0
Target:  

IMPDH

Research Areas:  

Cancer

IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers .
loading...
    loading...
Cat. No.: HY-161175
CAS No.: 3026255-85-3
Target:  

Hedgehog

Research Areas:  

Cancer

IMP-1575 is the most potent Hedgehog acyltransferase (HHAT) inhibitor, with an IC50 of 0.75 μM for inhibition of purified HHAT. IMP-1575 can be used for the research of cancer .
loading...
    loading...
Cat. No.: HY-W703376
CAS No.: 63199-74-6
2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride (Compound Imp.1) is a non-selective monoamine transporter (DAT/NET/SERT) agonist. tert-Butylcathinone hydrochloride is promising for research of depressive disorders .
loading...
    loading...
Cat. No.: HY-12826
CAS No.: 292057-76-2
Purity:  ≥98.0%
Research Areas:  

Cancer

IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1) . IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively .
loading...
    loading...
Cat. No.: HY-137724
CAS No.: 79940-41-3
Synonyms: Cyclic-di-IMP
Target:  

STING

Research Areas:  

Cancer

C-di-IMP (Cyclic-di-IMP) is a STING agonist. C-di-IMP can be used for the research of tumor .
loading...
    loading...
Cat. No.: HY-164434
CAS No.: 523-98-8
Synonyms: 5'-Xanthylic acid
Target:  

Endogenous Metabolite

Research Areas:  

Others

Xanthosine-5'-monophosphate can be obtained by catalyzing inosine 5'-monophosphate (IMP) with inosine 5'-monophosphate dehydrogenase (IMPDH) .
loading...
    loading...
Cat. No.: HY-10250
CAS No.: 61966-08-3
Synonyms: TCN-P
Target:  

ATP Synthase

Research Areas:  

Metabolic Disease Cancer

Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits  IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
loading...
    loading...
Cat. No.: HY-175488
Research Areas:  

Infection

RPX 7546 is a potent inhibitor of metallo-𝛽-lactamases (MBLs) with IC50 values of 1.4 and 48 μM for IMP-1 and IMP-78, respectively. RPX 7546 has antibacterial activity .
loading...
    loading...
Cat. No.: HY-176519
CAS No.: 2270184-16-0
Research Areas:  

Infection

ANT2681 is a potent NDM inhibitor with a Ki value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae .
loading...
    loading...
Cat. No.: HY-W009666
CAS No.: 118289-55-7
Target:  

Dopamine Transporter

Research Areas:  

Others

6-Chloro-5-(2-chloroethyl)oxindole (Imp Z2) is an impurity of Ziprasidone (HY-14542), a substrate of the human dopamine transporter (hDAT) .
loading...
    loading...
Cat. No.: HY-136498
CAS No.: 356783-08-9
Target:  

Drug Metabolite

Research Areas:  

Infection

T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM .
loading...
    loading...
Cat. No.: HY-150255
CAS No.: 1448353-63-6
Target:  

IGF-1R Insulin Receptor

Research Areas:  

Cancer

IMP2-IN-3 is a potent IMP2 inhibitor. IMP2-IN-3 shows anticancer effects .
loading...
    loading...
Cat. No.: HY-155470
CAS No.: 391267-29-1
Research Areas:  

Cancer

IMP 243 is a symmetric di-HSG (histamine-succinyl-glycine) bivalent hapten containing a Tscg-Cys ligand and two HSG groups. IMP 243 can be radiolabeled with 99mTc-pertechnetate. IMP 243 can be conjugated to other peptides to design bispecific antibodies (bsMAbs) for cancer research .
loading...
    loading...
Cat. No.: HY-137724A
Purity:  99.9%
Synonyms: Cyclic-di-IMP disodium
Target:  

STING

Research Areas:  

Cancer

C-di-IMP disodium is a STING agonist. C-di-IMP disodium can be used in tumor research .
loading...
    loading...
Cat. No.: HY-155471
CAS No.: 608489-42-5
Research Areas:  

Others

IMP 245 is a symmetric di-HSG bivalent hapten. IMP 245 has low toxicity, high affinity binding to available antibodies and absence of cross reactivity or non-specific binding with body components .
loading...
    loading...
Cat. No.: HY-155469
CAS No.: 391267-27-9
Target:  

Hapten

Research Areas:  

Others

IMP 241 is a di-HSG bivalent hapten .
loading...
    loading...
Cat. No.: HY-RS06793
Research Areas:  

Others

IMP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IMP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...