39 Results for "

SSTR2

" in MedChemExpress (MCE) Product Catalog:
Products (39)

39 Results for "SSTR2" in MCE Product Catalog:

Cat. No.: HY-163317
Target:  

Somatostatin Receptor

Research Areas:  

Cancer

MMC(TMZ)-TOC has high binding affinity and selectivity for somatostatin receptor subtype-2 (SSTR2). MMC(TMZ)-TOC targets delivery of TMZ to SSTR2-positive tumor cells. MMC(TMZ)-TOC can be used for the research of cancer .
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Cat. No.: HY-P5362A
NODAGA-LM3 TFA is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC50 = 1.3 nM). NODAGA-LM3 TFA does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 TFA shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. 68Ga-labeled NODAGA-LM3 TFA can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors [2].
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Cat. No.: HY-P4555
CAS No.: 340821-13-8
Target:  

Somatostatin Receptor

Research Areas:  

Neurological Disease

(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) is a somatostatin analog with Kds of 0.61, 11.05, 23.5, 1200 and >1000 nM for SSTR5, SSTR3, SSTR2, SSTR1 and SSTR4, respectively .
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Cat. No.: HY-P0024
CAS No.: 252845-37-7
Synonyms: DG3173; PTR-3173
Target:  

Somatostatin Receptor

Research Areas:  

Endocrinology Cancer

Veldoreotide (DG3173) a somatostatin analogue, binds to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits growth hormone (GH) secretion in adenomas compared withOctreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent
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Cat. No.: HY-Z15823
CAS No.: 38321-02-7
Synonyms: Dexverapamil
(R)-Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil (HY-14275). (R)-Verapamil has a relatively low affinity for L-type calcium channels (Cav1.2) (IC50 > 300 μM), and its IC50 for sodium channels (sodium channel) is 3.19 μM. (R)-Verapamil exhibits SSTR2 agonistic activity, with an EC50 of 1.3 μM. (R)-Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R)-Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp) [2] .
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Cat. No.: HY-P0036D
CAS No.: 1427427-01-7
NOTA‑Octreotide is a selective SSTR2‑targeting PET tracer. NOTA‑Octreotide binds specifically to SSTR2 and accumulates in SSTR2‑expressing tissues. NOTA‑Octreotide enables effective imaging of somatostatin receptor‑positive tumors in mice and shows high specific uptake in SSTR2‑expressing organs in healthy rats. NOTA-Octreotide can be used for PET imaging investigation of neuroendocrine tumors. .
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Cat. No.: HY-P11655
CAS No.: 709043-21-0
Target:  

Somatostatin Receptor

Research Areas:  

Neurological Disease

NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours .
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Cat. No.: HY-P2150
CAS No.: 1815618-17-7
Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects [2] .
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Cat. No.: HY-P704897
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: SSTR2; SST2; Somatostatin Receptor 2; SS2R; Somatostatin Receptor Type 2; SS-2-R; SRIF-1; SS2-R
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700430
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: SSTR2; SST2; Somatostatin Receptor 2; SS2R; Somatostatin Receptor Type 2; SS-2-R; SRIF-1; SS2-R
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P704898
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: SSTR2; SST2; Somatostatin Receptor 2; SS2R; Somatostatin Receptor Type 2; SS-2-R; SRIF-1; SS2-R
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P11924
Research Areas:  

Cancer

TATE-DA-I is a somatostatin receptor 2 (SSTR2) ligand with an IC50 of 25.3 nM. TATE-DA-I binds to albumin to prolong its circulation retention time and also exhibits enhanced tumor accumulation capacity. TATE-DA-I enables clear visualization of SSTR2-positive tumors in SPECT/CT imaging. TATE-DA-I can be used in cancer-related research .
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Cat. No.: HY-P11900
Ac-crown-TATE is an actinium-labeled radioligand derived from the SSTR2 agonist crown-TATE, which targets neuroendocrine tumors with high SSTR2 expression. The [226Ac]Ac-crown-TATE form of Ac-crown-TATE possesses both SPECT-detectable γ-emission and α-radiation properties, and it inhibits tumor growth and prolongs survival. Ac-crown-TATE can be used in studies of SSTR2-positive neuroendocrine tumors, targeted α-radiation, and radionuclide imaging [2] .
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Cat. No.: HY-P81452
Synonyms: SSTR2; somatostatin receptor 2; SS 2 R; SS2R; SRIF 1; SS2 R

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human

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Cat. No.: HY-P11485
JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC50 s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [ 68Ga]. [ 68Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .
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Cat. No.: HY-P11488
JR11-PEG3-DOTA-PSMA-03 (Compound 2) is an RDC-related compound containing the chelating agent DOTA (HY-W053583), the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-DOTA-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC50 s of 94.0 nM, 81.8 nM, respectively. JR11-PEG3-DOTA-PSMA-03 can be radiolabeled with [ 68Ga]. [ 68Ga] radiolabeled JR11-PEG3-DOTA-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .
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Cat. No.: HY-P81452A
Synonyms: SSTR2; somatostatin receptor 2; SS 2 R; SS2R; SRIF 1; SS2 R

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human

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Cat. No.: HY-P84249A
Synonyms: Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R, SST2, SRIF-1, SSTR2

Host:  

Mouse

Application:  

FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-106033R
CAS No.: 204318-14-9
Synonyms: DOTATOC (Standard); SDZ-SMT 487 (Standard); SMT 487 (Standard)
Edotreotide (Standard) is the analytical standard of Edotreotide (HY-106033). This product is intended for research and analytical applications. Edotreotide is a ligand that selectively targets SSTR2 and can competitively bind to the receptor. Edotreotide mediates the targeted delivery, while modificated with radionuclides (such as 90Y, 177Lu, and 68Ga) to SSTR-positive tumors and induces tumor cell apoptosis by releasing β rays. Edotreotide has strong tumor targeting and precise killing activity. Edotreotide is used in the synthesis of radionuclide-drug conjugates (RDCs) and is widely used in the field of neuroendocrine tumors (such as metastatic carcinoids, lung and thymus NETs) [2] .
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