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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
integrin-alpha-5
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "integrin-alpha-5" in MCE Product Catalog:
Cat. No.: HY-150124A
CAS No.: 2986315-25-5
K34c hydrochloride is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c hydrochloride reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c hydrochloride can be used in glioblastoma research .
Cat. No.: HY-111413
CAS No.: 1844830-65-4
Cat. No.: HY-P5038
CAS No.: 135432-37-0
Synonyms: c(GRGDSP)
Cat. No.: HY-P991652
Synonyms: RG-7594
Cat. No.: HY-16141R
CAS No.: 188968-51-6
Synonyms: EMD 121974 (Standard)
Cilengitide (Standard) (EMD 121974 (Standard)) is the analytical standard of Cilengitide (HY-16141). This product is intended for research and analytical applications. Cilengitide (EMD 121974) is an integrin (integrin) inhibitor with blood-brain barrier permeability, with IC50 values against human targets as follows: 0.61 nM for αvβ3, 8.4 nM for αvβ5, 14.9 nM for α5β1, 5400 nM for αIIbβ3, 2050 nM for αvβ6, 2350 nM for αvβ8. Cilengitide inhibits the binding of integrins to vitronectin, fibronectin, fibrinogen and LAP (TGF-β), and serves as an internal standard for solid-phase integrin binding assays. Cilengitide inhibits tumor cell viability, induces apoptosis, reduces the phosphorylation levels of STAT3, AKT and mTOR, downregulates the expression of PD-L1, inhibits cell viability and angiogenesis, regulates anti-tumor immune responses and slows tumor growth. Cilengitide can be used in research related to glioblastoma, melanoma, advanced solid tumors and refractory brain tumors .
Cat. No.: HY-P10993
CAS No.: 1407967-57-0
Target:
Research Areas:
Cat. No.: HY-156521
CAS No.: 2234874-68-9
αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC50s of 0.9 nM，and 33 nM，respectively. αvβ1 integrin-IN-2 also inhibits other integrins with ，，IC50s of 380 nM (ανβ3)，280 nM (ανβ5)，230 nM (ανβ6)，87 nM (ανβ8)，respectively，in SPRA assay .
Cat. No.: HY-180057
CAS No.: 2649899-08-9
Target:
Research Areas:
α5β1 integrin-IN-1 is a potent and selective α5β1 integrin inhibitor with an IC50 value of approximately 0.4 nM (pIC50 = 9.4 M). α5β1 integrin-IN-1 disrupts the interaction between α5β1 integrin and fibronectin, thereby blocking smooth muscle tension transmission and α5β1 integrin-mediated cell adhesion. α5β1 integrin-IN-1 can be used in the research of asthma and allergic asthma.
Cat. No.: HY-126402
CAS No.: 120103-89-1
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1. It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.
Cat. No.: HY-P992084
Target:
Research Areas:
Cat. No.: HY-P73872
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGA5; integrin alpha-F; Prev. FNRA; CDNA FLJ50382, Moderately Similar To integrin alpha-5; CD49e; Very Late Activation Protein 5, alpha Subunit; integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide); Fibronectin Receptor, alpha Subunit; Fibronectin
Species:
Human
Source:
HEK293
Cat. No.: HY-P72533
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGA5; integrin alpha-F; Prev. FNRA; CDNA FLJ50382, Moderately Similar To integrin alpha-5; CD49e; Very Late Activation Protein 5, alpha Subunit; integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide); Fibronectin Receptor, alpha Subunit; Fibronectin
Species:
Human
Source:
HEK293
Cat. No.: HY-P704259
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGA5; integrin alpha-F; Prev. FNRA; CDNA FLJ50382, Moderately Similar To integrin alpha-5; CD49e; Very Late Activation Protein 5, alpha Subunit; integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide); Fibronectin Receptor, alpha Subunit; Fibronectin
Species:
Human
Source:
HEK293
Cat. No.: HY-P706168
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGA5; integrin alpha-F; Prev. FNRA; CDNA FLJ50382, Moderately Similar To integrin alpha-5; CD49e; Very Late Activation Protein 5, alpha Subunit; integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide); Fibronectin Receptor, alpha Subunit; Fibronectin
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P700755
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGA5; integrin alpha-F; Prev. FNRA; CDNA FLJ50382, Moderately Similar To integrin alpha-5; CD49e; Very Late Activation Protein 5, alpha Subunit; integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide); Fibronectin Receptor, alpha Subunit; Fibronectin
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
