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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
open angle glaucoma
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "open angle glaucoma" in MCE Product Catalog:
Cat. No.: HY-119732
CAS No.: 2134571-29-0
Target:
Research Areas:
KUNG94 is a selective Grp94/HSP90B inhibitor (IC50=8 nM). By inhibiting the chaperone function of Grp94, KUNG94 reduces the maturation and cell surface trafficking of its specific client proteins. KUNG94 can be used for studies on Grp94-related biological mechanisms, as well as diseases including cancer and primary open-angle glaucoma .
Cat. No.: HY-182426
CAS No.: 1202697-61-7
Target:
Research Areas:
NCX-278 is a human carbonic anhydrase inhibitor with a 13 nM Ki for hCA II, 410 nM Ki for hCA I, 181 nM Ki for hCA IV, and selective inhibition of hCA II over hCA IV. NCX-278 is a potent and effective stimulator of NO/sGC/cGMP signaling with an EC50 of 2.05 lM. NCX-278 exerts NO-mediated vascular relaxant effects. NCX-278 lowers intraocular pressure in normotensive rabbits. NCX-278 can be used for the research of open-angle glaucoma .
Cat. No.: HY-B0109H
CAS No.: 120279-95-0
Synonyms: (4R,6R)-L671152; (4R,6R)-MK507
Research Areas:
(4R,6R)-Dorzolamide ((4R,6R)-L671152; (4R,6R)-MK507) is a carbonic anhydrase II (CAII) inhibitor and the undesired chiral enantiomer of Dorzolamide. (4R,6R)-Dorzolamide inhibits CAII isoenzymes, thereby modulating the rate of aqueous humor formation. (4R,6R)-Dorzolamide serves as a stereoisomeric reference standard in chiral HPLC separation studies. (4R,6R)-Dorzolamide can be used for research on ocular hypertension and glaucoma .
Cat. No.: HY-180195
Research Areas:
Grp94-IN-3 (Compound 47) is a selective ATP competitive inhibitor of Grp94, with a Kd value of 76 nM. Grp94-IN-3 has a much lower affinity for Hsp90α, with a Kd value of 9.17 μM. Grp94-IN-3 induces the degradation of integrin α2 (Integrin α2) in MDA-MB-231 cells and reduces the intracellular accumulation of mutant cardiac proteins in human trabecular meshwork cells. Grp94-IN-3 can be used for the study of metastatic cancer and open-angle glaucoma .
Cat. No.: HY-P77920
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: EFEMP1; FIBL-3; Prev. FBNL; glaucoma 1, open angle, H (Adult-Onset); Prev. DHRD; Uncharacterized Protein EFEMP1; EGF-Containing Fibulin-Like Extracellular Matrix Protein 1; HCG16977, Isoform CRA_b; EGF Containing Fibulin Extracellular Matrix Protein 1; Fi
Species:
Human
Source:
HEK293
Cat. No.: HY-P77921
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: EFEMP1; FIBL-3; Prev. FBNL; glaucoma 1, open angle, H (Adult-Onset); Prev. DHRD; Uncharacterized Protein EFEMP1; EGF-Containing Fibulin-Like Extracellular Matrix Protein 1; HCG16977, Isoform CRA_b; EGF Containing Fibulin Extracellular Matrix Protein 1; Fi
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
