1202697-61-7
Chemical Structure
NCX-278
- CAS No.: 1202697-61-7
- Formula:C14H21N3O9S3
- Molecular Weight:471.53
InChIKey: WMNLMYBKRKWSIH-ONGXEEELSA-N
SMILES: O=C(OCCCO[N+]([O-])=O)N([C@@H]1C2=C(S(=O)([C@H](C1)C)=O)SC(S(N)(=O)=O)=C2)CC
Biological Activity: NCX-278 is a human carbonic anhydrase inhibitor with a 13 nM Ki for hCA II, 410 nM Ki for hCA I, 181 nM Ki for hCA IV, and selective inhibition of hCA II over hCA IV. NCX-278 is a potent and effective stimulator of NO/sGC/cGMP signaling with an EC50 of 2.05 lM. NCX-278 exerts NO-mediated vascular relaxant effects. NCX-278 lowers intraocular pressure in normotensive rabbits. NCX-278 can be used for the research of open-angle glaucoma[1].
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NCX-278 | NCX-278 is a human carbonic anhydrase inhibitor with a 13 nM Ki for hCA II, 410 nM Ki for hCA I, 181 nM Ki for hCA IV, and selective inhibition of hCA II over hCA IV. NCX-278 is a potent and effective stimulator of NO/sGC/cGMP signaling with an EC50 of 2.05 lM. NCX-278 exerts NO-mediated vascular relaxant effects. NCX-278 lowers intraocular pressure in normotensive rabbits. NCX-278 can be used for the research of open-angle glaucoma. | |||||||||||||||||||||
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